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Septin4 Gene Detail
Summary
  • Symbol
    Septin4
  • Name
    septin 4
  • Synonyms
    ARTS, Bh5, cell division control-related protein 2b, Gm11492, Pnutl2, Sept4, septin H5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270156
    NCBI Gene: 18952
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87457515-87481365 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270156
 protein coding gene Chr11:87457479-87481365 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018906
 protein coding gene Chr11:89195160-89218258 (+)
A/J MGP_AJ_G0018873
 protein coding gene Chr11:85752340-85773924 (+)
AKR/J MGP_AKRJ_G0018843
 protein coding gene Chr11:88321583-88343187 (+)
BALB/cJ MGP_BALBcJ_G0018846
 protein coding gene Chr11:86148966-86171600 (+)
C3H/HeJ MGP_C3HHeJ_G0018660
 protein coding gene Chr11:88357201-88380668 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019298
 protein coding gene Chr11:91896981-91922965 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016931
 protein coding gene Chr11:82781984-82803554 (+)
CAST/EiJ MGP_CASTEiJ_G0018215
 protein coding gene Chr11:89048900-89072466 (+)
CBA/J MGP_CBAJ_G0018631
 protein coding gene Chr11:95751300-95780587 (+)
DBA/2J MGP_DBA2J_G0018739
 protein coding gene Chr11:85306419-85328344 (+)
FVB/NJ MGP_FVBNJ_G0018728
 protein coding gene Chr11:84813397-84835870 (+)
LP/J MGP_LPJ_G0018809
 protein coding gene Chr11:89686998-89708747 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018755
 protein coding gene Chr11:95813783-95836359 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019338
 protein coding gene Chr11:88559581-88581938 (+)
PWK/PhJ MGP_PWKPhJ_G0017985
 protein coding gene Chr11:86152725-86175499 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017778
 protein coding gene Chr11:88122206-88146133 (+)
WSB/EiJ MGP_WSBEiJ_G0018266
 protein coding gene Chr11:88436093-88460100 (+)



Homology
more
  • Human Ortholog
    SEPTIN4, septin 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEPTIN4, septin 4
  • Synonyms
    ARTS, BRADEION, C17orf47, CE5B3, H5, hCDCREL-2, hucep-7, MART, PNUTL2, SEP4, SEPT4, Septin-4
  • Links
    NCBI Gene ID: 5414
    neXtProt AC: NX_O43236
    UniProt: O43236

  • Chr Location
    17q22; chr17:58520250-58544368 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are sterile and have immotile and structurally defective sperm that is bent and lacks the annulus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    66
  • cDNA Data
    58
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18952 NCBI Gene Model | MGI Sequence Detail 23851 C57BL/6J ±  kb
    transcript NM_001424196 RefSeq | MGI Sequence Detail 3193 C57BL/6  
    polypeptide P28661 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 59
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3651136, MGI:6368833
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 9
      Gene Ontology 17
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:269496 Koren E, et al., ARTS mediates apoptosis and regeneration of the intestinal stem cell niche. Nat Commun. 2018 Nov 2;9(1):4582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/05/2024
    MGI 6.24     		The Jackson Laboratory