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Rps6kb1 Gene Detail
Summary
  • Symbol
    Rps6kb1
  • Name
    ribosomal protein S6 kinase, polypeptide 1
  • Synonyms
    2610318I15Rik, p70/85s6k, p70s6k, p70S6K1, S6K1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270849
    NCBI Gene: 72508
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:86389697-86435631 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    757 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270849
 protein coding gene Chr11:86389695-86435711 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018890
 protein coding gene Chr11:88057530-88106445 (-)
A/J MGP_AJ_G0018857
 protein coding gene Chr11:84672140-84720880 (-)
AKR/J MGP_AKRJ_G0018827
 protein coding gene Chr11:87205451-87253511 (-)
BALB/cJ MGP_BALBcJ_G0018830
 protein coding gene Chr11:85059734-85105753 (-)
C3H/HeJ MGP_C3HHeJ_G0018644
 protein coding gene Chr11:87234227-87282876 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019282
 protein coding gene Chr11:90724223-90774227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016915
 protein coding gene Chr11:81702592-81743986 (-)
CAST/EiJ MGP_CASTEiJ_G0018199
 protein coding gene Chr11:87916085-87967564 (-)
CBA/J MGP_CBAJ_G0018615
 protein coding gene Chr11:94539090-94592973 (-)
DBA/2J MGP_DBA2J_G0018723
 protein coding gene Chr11:84244307-84292165 (-)
FVB/NJ MGP_FVBNJ_G0018712
 protein coding gene Chr11:83746877-83794391 (-)
LP/J MGP_LPJ_G0018793
 protein coding gene Chr11:88549322-88598316 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018739
 protein coding gene Chr11:94647579-94695597 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019322
 protein coding gene Chr11:87451447-87498621 (-)
PWK/PhJ MGP_PWKPhJ_G0017968
 protein coding gene Chr11:85039288-85086270 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017760
 protein coding gene Chr11:87006292-87053776 (-)
WSB/EiJ MGP_WSBEiJ_G0018250
 protein coding gene Chr11:87324149-87372662 (-)



Homology
more
  • Human Ortholog
    RPS6KB1, ribosomal protein S6 kinase B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS6KB1, ribosomal protein S6 kinase B1
  • Synonyms
    p70-alpha, p70-S6K, p70 S6KA, p70(S6K)-alpha, PS6K, S6K, S6K1, S6K-beta-1, STK14A
  • Links
    NCBI Gene ID: 6198
    neXtProt AC: NX_P23443
    UniProt: P23443

  • Chr Location
    17q23.1; chr17:59893046-59950574 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    34 phenotypes from multigenic genotypes
    1 images
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced prenatal growth, glucose intolerance, and hypoinsulinemia associated with diminished pancreatic beta cell size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    131
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    48
  • cDNA Data
    25
  • Literature Summary
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020516 Ensembl Gene Model | MGI Sequence Detail 45935 C57BL/6J ±  kb
    transcript ENSMUST00000154617 Ensembl | MGI Sequence Detail 5531 Not Applicable  
    polypeptide ENSMUSP00000119715 Ensembl | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 28
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1919758, MGI:2144050, MGI:2144103, MGI:2144107
    References
    more
    • Summaries
      All 253
      Developmental Gene Expression 76
      Gene Ontology 22
      Phenotypes 75
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354208 Dong MZ, et al., Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes. Cell Death Dis. 2024 Sep 8;15(9):658
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory