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Guca2b Gene Detail
Summary
  • Symbol
    Guca2b
  • Name
    guanylate cyclase activator 2b
  • Synonyms
    Gcap2, uroguanylin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270851
    NCBI Gene: 14916
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119513798-119516142 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.48 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270851
 protein coding gene Chr4:119513798-119516151 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028704
 protein coding gene Chr4:120857413-120859674 (-)
A/J MGP_AJ_G0028664
 protein coding gene Chr4:116110690-116113991 (-)
AKR/J MGP_AKRJ_G0028617
 protein coding gene Chr4:118643083-118645380 (-)
BALB/cJ MGP_BALBcJ_G0028687
 protein coding gene Chr4:116739548-116741849 (-)
C3H/HeJ MGP_C3HHeJ_G0028402
 protein coding gene Chr4:120199434-120202459 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029128
 protein coding gene Chr4:125447332-125449628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026405
 protein coding gene Chr4:110204801-110207028 (-)
CAST/EiJ MGP_CASTEiJ_G0027833
 protein coding gene Chr4:117523876-117527384 (-)
CBA/J MGP_CBAJ_G0028369
 protein coding gene Chr4:128844768-128848443 (-)
DBA/2J MGP_DBA2J_G0028516
 protein coding gene Chr4:116699886-116702443 (-)
FVB/NJ MGP_FVBNJ_G0028482
 protein coding gene Chr4:115217521-115220385 (-)
LP/J MGP_LPJ_G0028616
 protein coding gene Chr4:120982980-120986288 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028510
 protein coding gene Chr4:133734195-133738590 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029165
 protein coding gene Chr4:119711448-119715020 (-)
PWK/PhJ MGP_PWKPhJ_G0027556
 protein coding gene Chr4:113628075-113630745 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027382
 protein coding gene Chr4:116151492-116153752 (-)
WSB/EiJ MGP_WSBEiJ_G0027913
 protein coding gene Chr4:119720121-119723984 (-)



Homology
more
  • Human Ortholog
    GUCA2B, guanylate cyclase activator 2B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCA2B, guanylate cyclase activator 2B
  • Synonyms
    GCAP-II, UGN
  • Links
    NCBI Gene ID: 2981
    neXtProt AC: NX_Q16661
    UniProt: Q16661

  • Chr Location
    1p34.2; chr1:42153410-42155820 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit elevated blood pressure, increased sodium levels, and reduced sodium, potassium, and fluid excretion following salt loading.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14916 NCBI Gene Model | MGI Sequence Detail 2345 C57BL/6J ±  kb
    transcript NM_008191 RefSeq | MGI Sequence Detail 602 C57BL/6  
    polypeptide O09051 UniProt | EBI | MGI Sequence Detail 106 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 3
      cDNA 42

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1354183, MGI:2140522
    References
    more
    • Summaries
      All 43
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
    • Latest
      J:338998 Ratko M, et al., Role of uroguanylin's signalling pathway in the development of ischaemic stroke. Eur J Neurosci. 2022 Jul;56(1):3720-3737
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory