About   Help   FAQ
Ptp4a3 Gene Detail
Summary
  • Symbol
    Ptp4a3
  • Name
    protein tyrosine phosphatase 4a3
  • Synonyms
    Prl-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277098
    NCBI Gene: 19245
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:73594991-73629075 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.05 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1086 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277098
 protein coding gene Chr15:73594991-73630615 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021924
 protein coding gene Chr15:73478805-73519609 (+)
A/J MGP_AJ_G0021883
 protein coding gene Chr15:70852766-70888385 (+)
AKR/J MGP_AKRJ_G0021865
 protein coding gene Chr15:72655855-72693134 (+)
BALB/cJ MGP_BALBcJ_G0021890
 protein coding gene Chr15:70857554-70894072 (+)
C3H/HeJ MGP_C3HHeJ_G0021663
 protein coding gene Chr15:72811406-72848132 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022330
 protein coding gene Chr15:76269407-76309219 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019866
 protein coding gene Chr15:67273071-67308564 (+)
CAST/EiJ MGP_CASTEiJ_G0021182
 protein coding gene Chr15:73612787-73648592 (+)
CBA/J MGP_CBAJ_G0021629
 protein coding gene Chr15:78763047-78801576 (+)
DBA/2J MGP_DBA2J_G0021754
 protein coding gene Chr15:70451204-70487483 (+)
FVB/NJ MGP_FVBNJ_G0021736
 protein coding gene Chr15:69472439-69509434 (+)
LP/J MGP_LPJ_G0021826
 protein coding gene Chr15:73503475-73540181 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021759
 protein coding gene Chr15:84118259-84154012 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022351
 protein coding gene Chr15:73052465-73088180 (+)
PWK/PhJ MGP_PWKPhJ_G0020923
 protein coding gene Chr15:70550455-70586594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020764
 protein coding gene Chr15:72944520-72980201 (+)
WSB/EiJ MGP_WSBEiJ_G0021234
 protein coding gene Chr15:73055005-73090723 (+)



Homology
more
  • Human Ortholog
    PTP4A3, protein tyrosine phosphatase 4A3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTP4A3, protein tyrosine phosphatase 4A3
  • Synonyms
    PRL-3, PRL3, PRL-R
  • Links
    NCBI Gene ID: 11156
    neXtProt AC: NX_O75365
    UniProt: O75365

  • Chr Location
    8q24.3; chr8:141391995-141432454 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial preweaning lethality and decreased incidence of AOM-DDS induced tumors. Mice homozygous for a different targeted allele exhibit decreased circulating glucose levels in an intraperitoneal glucose tolerance test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    37
  • cDNA Data
    94
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19245 NCBI Gene Model | MGI Sequence Detail 34085 C57BL/6J ±  kb
    transcript NM_001166388 RefSeq | MGI Sequence Detail 2430 C57BL/6  
    polypeptide Q9D658 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 95
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146167
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 10
      Phenotypes 36
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory