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Pde9a Gene Detail
Summary
  • Symbol
    Pde9a
  • Name
    phosphodiesterase 9A
  • Synonyms
    PDE9A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277179
    NCBI Gene: 18585
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31605184-31695284 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 16.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2679 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277179
 protein coding gene Chr17:31605079-31695284 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023488
 protein coding gene Chr17:31152479-31252633 (+)
A/J MGP_AJ_G0023446
 protein coding gene Chr17:30127232-30221829 (+)
AKR/J MGP_AKRJ_G0023411
 protein coding gene Chr17:30380903-30482459 (+)
BALB/cJ MGP_BALBcJ_G0023451
 protein coding gene Chr17:30226359-30317621 (+)
C3H/HeJ MGP_C3HHeJ_G0023212
 protein coding gene Chr17:30760534-30861746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023893
 protein coding gene Chr17:32232427-32330757 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021367
 protein coding gene Chr17:27260573-27349675 (+)
CAST/EiJ MGP_CASTEiJ_G0022713
 protein coding gene Chr17:30811179-30911033 (+)
CBA/J MGP_CBAJ_G0023187
 protein coding gene Chr17:33635564-33728028 (+)
DBA/2J MGP_DBA2J_G0023317
 protein coding gene Chr17:29533296-29624499 (+)
FVB/NJ MGP_FVBNJ_G0023287
 protein coding gene Chr17:29326948-29417835 (+)
LP/J MGP_LPJ_G0023395
 protein coding gene Chr17:31364084-31470029 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023305
 protein coding gene Chr17:32716277-32814256 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023935
 protein coding gene Chr17:30753456-30848914 (+)
PWK/PhJ MGP_PWKPhJ_G0022463
 protein coding gene Chr17:28399155-28494319 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022281
 protein coding gene Chr17:28728574-28826892 (+)
WSB/EiJ MGP_WSBEiJ_G0022775
 protein coding gene Chr17:30714318-30811498 (+)



Homology
more
  • Human Ortholog
    PDE9A, phosphodiesterase 9A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE9A, phosphodiesterase 9A
  • Synonyms
    HSPDE9A2
  • Links
    NCBI Gene ID: 5152
    neXtProt AC: NX_O76083
    UniProt: O76083

  • Chr Location
    21q22.3; chr21:42653621-42775509 (+)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit suppressed pressure-overload-induced cardiac pathobiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1211
  • Tissues
    186
  • cDNA Data
    14
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041119 Ensembl Gene Model | MGI Sequence Detail 90101 C57BL/6J ±  kb
    transcript ENSMUST00000047168 Ensembl | MGI Sequence Detail 2089 Not Applicable  
    polypeptide ENSMUSP00000038005 Ensembl | MGI Sequence Detail 534 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      19 Sequences
    • Protein Ontology
      PR:000012488 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.35
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003607 HD/PDEase domain
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 10
      Diseases 3
      Gene Ontology 12
      Phenotypes 35
    • Earliest
      J:48139 Soderling SH, et al., Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem. 1998 Jun 19;273(25):15553-8
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory