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Dach1 Gene Detail
Summary
  • Symbol
    Dach1
  • Name
    dachshund family transcription factor 1
  • Synonyms
    D6, Dac, E130112M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277991
    NCBI Gene: 13134
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:98024289-98407201 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 48.25 cM, cytoband E3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9698 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277991
 protein coding gene Chr14:98024289-98407208 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021613
 protein coding gene Chr14:94008188-94413665 (-)
A/J MGP_AJ_G0021571
 protein coding gene Chr14:91050995-91436197 (-)
AKR/J MGP_AKRJ_G0021547
 protein coding gene Chr14:93685812-94079498 (-)
BALB/cJ MGP_BALBcJ_G0021577
 protein coding gene Chr14:91321389-91705472 (-)
C3H/HeJ MGP_C3HHeJ_G0021355
 protein coding gene Chr14:93595742-93984179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022017
 protein coding gene Chr14:97837457-98236460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019557
 protein coding gene Chr14:88111804-88494753 (-)
CAST/EiJ MGP_CASTEiJ_G0020872
 protein coding gene Chr14:90852932-91268960 (-)
CBA/J MGP_CBAJ_G0021323
 protein coding gene Chr14:101446135-101888063 (-)
DBA/2J MGP_DBA2J_G0021447
 protein coding gene Chr14:90507795-90901269 (-)
FVB/NJ MGP_FVBNJ_G0021423
 protein coding gene Chr14:89514299-89928757 (-)
LP/J MGP_LPJ_G0021515
 protein coding gene Chr14:94792658-95214900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021451
 protein coding gene Chr14:104071452-104605031 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022040
 protein coding gene Chr14:93221744-93623005 (-)
PWK/PhJ MGP_PWKPhJ_G0020615
 protein coding gene Chr14:87466004-87859960 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020453
 protein coding gene Chr14:89145406-89555608 (-)
WSB/EiJ MGP_WSBEiJ_G0020925
 protein coding gene Chr14:93773047-94180190 (-)



Homology
more
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DACH1, dachshund family transcription factor 1
  • Synonyms
    DACH
  • Links
    NCBI Gene ID: 1602
    neXtProt AC: NX_Q9UI36
    UniProt: Q9UI36

  • Chr Location
    13q21.33; chr13:71437966-71867204 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 4 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1601
  • Tissues
    342
  • cDNA Data
    38
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055639 Ensembl Gene Model | MGI Sequence Detail 382913 C57BL/6J ±  kb
    transcript ENSMUST00000071533 Ensembl | MGI Sequence Detail 5219 Not Applicable  
    polypeptide ENSMUSP00000071464 Ensembl | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 2
      cDNA 38
      Primer pair 3
      Other 5

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2145601, MGI:2442731
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 46
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:38305 Stewart GJ, et al., Sequence analysis of 497 mouse brain ESTs expressed in the substantia nigra. Genomics. 1997 Jan 15;39(2):147-53
    • Latest
      J:350367 Tanaka K, et al., Dach1 is essential for maintaining normal mature podocytes. PLoS One. 2024;19(5):e0303910
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory