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Lnx1 Gene Detail
Summary
  • Symbol
    Lnx1
  • Name
    ligand of numb-protein X 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278335
    NCBI Gene: 16924
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:74753108-74863573 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 39.52 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278335
 protein coding gene Chr5:74753108-74865203 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029634
 protein coding gene Chr5:74684030-74803541 (-)
A/J MGP_AJ_G0029602
 protein coding gene Chr5:71848698-71959321 (-)
AKR/J MGP_AKRJ_G0029550
 protein coding gene Chr5:74200707-74313999 (-)
BALB/cJ MGP_BALBcJ_G0029611
 protein coding gene Chr5:72561743-72675026 (-)
C3H/HeJ MGP_C3HHeJ_G0029334
 protein coding gene Chr5:74582194-74697571 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030065
 protein coding gene Chr5:77709116-77823365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027305
 protein coding gene Chr5:67514230-67625884 (-)
CAST/EiJ MGP_CASTEiJ_G0028742
 protein coding gene Chr5:73678354-73794342 (-)
CBA/J MGP_CBAJ_G0029303
 protein coding gene Chr5:80280446-80404904 (-)
DBA/2J MGP_DBA2J_G0029448
 protein coding gene Chr5:71934308-72050192 (-)
FVB/NJ MGP_FVBNJ_G0029409
 protein coding gene Chr5:71081930-71193290 (-)
LP/J MGP_LPJ_G0029534
 protein coding gene Chr5:75117354-75235235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029436
 protein coding gene Chr5:83507530-83620652 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030098
 protein coding gene Chr5:73725955-73839776 (-)
PWK/PhJ MGP_PWKPhJ_G0028465
 protein coding gene Chr5:70902215-71014587 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028300
 protein coding gene Chr5:73078268-73191904 (-)
WSB/EiJ MGP_WSBEiJ_G0028822
 protein coding gene Chr5:74013392-74128140 (-)



Homology
more
  • Human Ortholog
    LNX1, ligand of numb-protein X 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LNX1, ligand of numb-protein X 1
  • Synonyms
    LNX, MPDZ, PDZRN2
  • Links
    NCBI Gene ID: 84708
    neXtProt AC: NX_Q8TBB1
    UniProt: Q8TBB1

  • Chr Location
    4q12; chr4:53459301-53701405 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    367 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    1
  • Genomic Mutations
    6 involving Lnx1
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    43 strains or lines available
Mice homozygous for a targeted mutation exhibit an increased percentage of B1-like B cells in peritoneal lavage when compared with that of controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    46
  • cDNA Data
    10
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029228 Ensembl Gene Model | MGI Sequence Detail 110466 C57BL/6J ±  kb
transcript ENSMUST00000117388 Ensembl | MGI Sequence Detail 2564 Not Applicable  
polypeptide ENSMUSP00000113035 Ensembl | MGI Sequence Detail 728 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 400
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 9
    Phenotypes 367
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:358639 Su Y, et al., Brainstem Dbh(+) neurons control allergen-induced airway hyperreactivity. Nature. 2024 Jul;631(8021):601-609
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory