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Tax1bp1 Gene Detail
Summary
  • Symbol
    Tax1bp1
  • Name
    Tax1 (human T cell leukemia virus type I) binding protein 1
  • Synonyms
    1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289308
    NCBI Gene: 52440
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52690714-52743765 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.70 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    927 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289308
 protein coding gene Chr6:52690677-52743765 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030753
 protein coding gene Chr6:52000514-52057094 (+)
A/J MGP_AJ_G0030722
 protein coding gene Chr6:49571621-49624837 (+)
AKR/J MGP_AKRJ_G0030649
 protein coding gene Chr6:51294355-51348096 (+)
BALB/cJ MGP_BALBcJ_G0030734
 protein coding gene Chr6:49919002-49973335 (+)
C3H/HeJ MGP_C3HHeJ_G0030447
 protein coding gene Chr6:51294740-51350032 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031189
 protein coding gene Chr6:53144986-53204714 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028395
 protein coding gene Chr6:47199854-47259446 (+)
CAST/EiJ MGP_CASTEiJ_G0029850
 protein coding gene Chr6:51117220-51176202 (+)
CBA/J MGP_CBAJ_G0030421
 protein coding gene Chr6:55371714-55433506 (+)
DBA/2J MGP_DBA2J_G0030571
 protein coding gene Chr6:49482089-49534922 (+)
FVB/NJ MGP_FVBNJ_G0030523
 protein coding gene Chr6:49083104-49136284 (+)
LP/J MGP_LPJ_G0030656
 protein coding gene Chr6:51958721-52016499 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030557
 protein coding gene Chr6:57978955-58038066 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031219
 protein coding gene Chr6:51234218-51286356 (+)
PWK/PhJ MGP_PWKPhJ_G0029563
 protein coding gene Chr6:49108405-49163987 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029397
 protein coding gene Chr6:50554840-50612558 (+)
WSB/EiJ MGP_WSBEiJ_G0029927
 protein coding gene Chr6:51227750-51283747 (+)



Homology
more
  • Human Ortholog
    TAX1BP1, Tax1 binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAX1BP1, Tax1 binding protein 1
  • Synonyms
    CALCOCO3, T6BP, TXBP151
  • Links
    NCBI Gene ID: 8887
    neXtProt AC: NX_Q86VP1
    UniProt: Q86VP1

  • Chr Location
    7p15.2; chr7:27739331-27844564 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout mice are born alive but fail to thrive and develop inflammatory cardiac valvulitis and dermatitis, die prematurely, and are hypersensitive to low doses of TNF and IL-1beta. In contrast, embryos homozygous for a gene trap mutation die at E13.5 from hemorrhaging and/or cardiac defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    7
  • cDNA Data
    351
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004535 Ensembl Gene Model | MGI Sequence Detail 53052 C57BL/6J ±  kb
    transcript ENSMUST00000080723 Ensembl | MGI Sequence Detail 3285 Not Applicable  
    polypeptide ENSMUSP00000079548 Ensembl | MGI Sequence Detail 814 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 356
      cDNA 353
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1196306, MGI:1889378, MGI:1914122, MGI:1920756
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:300172 Sarraf SA, et al., Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Mol Cell. 2020 Dec 3;80(5):779-795.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory