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Gzmk Gene Detail
Summary
  • Symbol
    Gzmk
  • Name
    granzyme K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298232
    NCBI Gene: 14945
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:113308164-113317499 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    417 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298232
 protein coding gene Chr13:113308142-113362442 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020949
 protein coding gene Chr13:115793042-115851447 (-)
A/J MGP_AJ_G0020899
 protein coding gene Chr13:111169667-111230467 (-)
AKR/J MGP_AKRJ_G0020874
 protein coding gene Chr13:114511618-114568292 (-)
BALB/cJ MGP_BALBcJ_G0020899
 protein coding gene Chr13:111852951-111907616 (-)
C3H/HeJ MGP_C3HHeJ_G0020688
 protein coding gene Chr13:114293744-114357343 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021335
 protein coding gene Chr13:119221220-119279021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018904
 protein coding gene Chr13:106455014-106511978 (-)
CAST/EiJ MGP_CASTEiJ_G0020207
 protein coding gene Chr13:113948212-113959399 (-)
CBA/J MGP_CBAJ_G0020650
 protein coding gene Chr13:123803343-123857355 (-)
DBA/2J MGP_DBA2J_G0020773
 protein coding gene Chr13:110872715-110928215 (-)
FVB/NJ MGP_FVBNJ_G0020757
 protein coding gene Chr13:109566321-109620326 (-)
LP/J MGP_LPJ_G0020849
 protein coding gene Chr13:115835552-115895423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020785
 protein coding gene Chr13:124089278-124146946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021371
 protein coding gene Chr13:113995157-114051786 (-)
PWK/PhJ MGP_PWKPhJ_G0019961
 protein coding gene Chr13:109634885-109692783 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019782
 protein coding gene Chr13:110290997-110354215 (-)
WSB/EiJ MGP_WSBEiJ_G0020265
 protein coding gene Chr13:114573731-114631616 (-)



Homology
more
  • Human Ortholog
    GZMK, granzyme K
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GZMK, granzyme K
  • Synonyms
    TRYP2
  • Links
    NCBI Gene ID: 3003
    neXtProt AC: NX_P49863
    UniProt: P49863

  • Chr Location
    5q11.2; chr5:55024256-55034570 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Mice homozygous for a knock-out allele are healthy, anatomically normal, fertile and show normal hematopoietic development and normal recovery from lymphocytic choriomeningitis virus and Ectromelia virus infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    39
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14945 NCBI Gene Model | MGI Sequence Detail 9336 C57BL/6J ±  kb
transcript NM_008196 RefSeq | MGI Sequence Detail 1104 C57BL/6  
polypeptide O35205 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 4
    cDNA 6
    Primer pair 4
    Other 4

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:49361 Shresta S, et al., Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. J Biol Chem. 1997 Aug 8;272(32):20236-44
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory