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Dio3 Gene Detail
Summary
  • Symbol
    Dio3
  • Name
    deiodinase, iodothyronine type III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306782
    NCBI Gene: 107585
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Regulated by
    Rr198, Rr199, Igdmr ... (4 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr12:110245664-110247531 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.56 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306782
 protein coding gene Chr12:110245502-110247531 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020116
 protein coding gene Chr12:112560353-112562382 (+)
A/J MGP_AJ_G0020070
 protein coding gene Chr12:108206440-108208469 (+)
AKR/J MGP_AKRJ_G0020046
 protein coding gene Chr12:111374765-111376793 (+)
BALB/cJ MGP_BALBcJ_G0020056
 protein coding gene Chr12:108683646-108685675 (+)
C3H/HeJ MGP_C3HHeJ_G0019858
 protein coding gene Chr12:111819610-111821639 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020501
 protein coding gene Chr12:116001616-116003645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018113
 protein coding gene Chr12:104710790-104712821 (+)
CAST/EiJ MGP_CASTEiJ_G0019400
 protein coding gene Chr12:106771962-106773991 (+)
CBA/J MGP_CBAJ_G0019825
 protein coding gene Chr12:120511813-120513842 (+)
DBA/2J MGP_DBA2J_G0019942
 protein coding gene Chr12:107752375-107754403 (+)
FVB/NJ MGP_FVBNJ_G0019927
 protein coding gene Chr12:106553736-106555765 (+)
LP/J MGP_LPJ_G0020017
 protein coding gene Chr12:112394732-112396761 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019965
 protein coding gene Chr12:123667136-123669164 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020530
 protein coding gene Chr12:110851274-110853303 (+)
PWK/PhJ MGP_PWKPhJ_G0019159
 protein coding gene Chr12:102367046-102369075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018963
 protein coding gene Chr12:105018042-105020072 (+)
WSB/EiJ MGP_WSBEiJ_G0019457
 protein coding gene Chr12:111764960-111766989 (+)



Homology
more
  • Human Ortholog
    DIO3, iodothyronine deiodinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DIO3, iodothyronine deiodinase 3
  • Synonyms
    5DIII, D3, DIOIII, TXDI3
  • Links
    NCBI Gene ID: 1735
    neXtProt AC: NX_P55073
    UniProt: P55073

  • Chr Location
    14q32.31; chr14:101560139-101563452 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial embryonic or perinatal mortality, growth retardation, reduced fertility, and severe anomalies in thyroid status and physiology, including reduced T3 clearance and neonatal thyrotoxicosis followed by central hypothyroidism that persists throughout life.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1042
  • Tissues
    175
  • cDNA Data
    10
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107585 NCBI Gene Model | MGI Sequence Detail 1868 C57BL/6J ±  kb
    transcript NM_172119 RefSeq | MGI Sequence Detail 1872 C57BL/6  
    polypeptide Q91ZI8 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 3
      cDNA 11
      Primer pair 12
      Other 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 44
      Gene Ontology 13
      Phenotypes 30
    • Earliest
      J:50456 Hernandez A, et al., Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. Genomics. 1998 Oct 1;53(1):119-21
    • Latest
      J:360773 Zheng W, et al., TFEB safeguards trophoblast syncytialization in humans and mice. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2404062121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory