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Aoc3 Gene Detail
Summary
  • Symbol
    Aoc3
  • Name
    amine oxidase, copper containing 3
  • Synonyms
    semicarbazide-sensitive amine oxidase, SSAO, VAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306797
    NCBI Gene: 11754
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101221432-101230256 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.72 cM, cytoband B2-B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    303 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306797
 protein coding gene Chr11:101221431-101232764 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019196
 protein coding gene Chr11:104175389-104186604 (+)
A/J MGP_AJ_G0019164
 protein coding gene Chr11:99798249-99811705 (+)
AKR/J MGP_AKRJ_G0019133
 protein coding gene Chr11:102899730-102912634 (+)
BALB/cJ MGP_BALBcJ_G0019138
 protein coding gene Chr11:100285241-100297657 (+)
C3H/HeJ MGP_C3HHeJ_G0018947
 protein coding gene Chr11:103076074-103088348 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019587
 protein coding gene Chr11:107431337-107450227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017213
 protein coding gene Chr11:97211422-97222791 (+)
CAST/EiJ MGP_CASTEiJ_G0018501
 protein coding gene Chr11:104065710-104076933 (+)
CBA/J MGP_CBAJ_G0018916
 protein coding gene Chr11:111865700-111885288 (+)
DBA/2J MGP_DBA2J_G0019028
 protein coding gene Chr11:99326713-99339574 (+)
FVB/NJ MGP_FVBNJ_G0019018
 protein coding gene Chr11:98875062-98885975 (+)
LP/J MGP_LPJ_G0019097
 protein coding gene Chr11:104723619-104734681 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019049
 protein coding gene Chr11:111428986-111440254 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019625
 protein coding gene Chr11:103227673-103238935 (+)
PWK/PhJ MGP_PWKPhJ_G0018264
 protein coding gene Chr11:100382831-100394377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018056
 protein coding gene Chr11:102963422-102974541 (+)
WSB/EiJ MGP_WSBEiJ_G0018550
 protein coding gene Chr11:103225380-103239456 (+)



Homology
more
  • Human Ortholog
    AOC3, amine oxidase copper containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AOC3, amine oxidase copper containing 3
  • Synonyms
    HPAO, SSAO, VAP-1, VAP1
  • Links
    NCBI Gene ID: 8639
    neXtProt AC: NX_Q16853
    UniProt: Q16853

  • Chr Location
    17q21.31; chr17:42851184-42858130 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased lymphocyte migration and homing in response to inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    916
  • Tissues
    165
  • cDNA Data
    18
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11754 NCBI Gene Model | MGI Sequence Detail 8825 C57BL/6J ±  kb
transcript NM_009675 RefSeq | MGI Sequence Detail 4396 C57BL/6  
polypeptide O70423 UniProt | EBI | MGI Sequence Detail 765 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 6
    cDNA 18
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 76
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:47790 Bono P, et al., Cloning and characterization of mouse vascular adhesion protein-1 reveals a novel molecule with enzymatic activity. J Immunol. 1998 Jun 1;160(11):5563-71
  • Latest
    J:309136 Jargaud V, et al., Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity. J Physiol Biochem. 2021 Feb;77(1):141-154
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory