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Gsta4 Gene Detail
Summary
  • Symbol
    Gsta4
  • Name
    glutathione S-transferase, alpha 4
  • Synonyms
    GST 5.7, mGsta4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309515
    NCBI Gene: 14860
  • Member of
    Gsta cluster
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78099248-78116631 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.65 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309515
 protein coding gene Chr9:78090056-78116631 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035059
 protein coding gene Chr9:78662739-78680099 (+)
A/J MGP_AJ_G0035040
 protein coding gene Chr9:75916883-75934362 (+)
AKR/J MGP_AKRJ_G0034969
 protein coding gene Chr9:77721057-77738541 (+)
BALB/cJ MGP_BALBcJ_G0035032
 protein coding gene Chr9:75597210-75614695 (+)
C3H/HeJ MGP_C3HHeJ_G0034741
 protein coding gene Chr9:78239190-78256674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035550
 protein coding gene Chr9:80769833-80787193 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032461
 protein coding gene Chr9:75148450-75163495 (+)
CAST/EiJ MGP_CASTEiJ_G0034063
 protein coding gene Chr9:78585015-78600607 (+)
CBA/J MGP_CBAJ_G0034713
 protein coding gene Chr9:83538654-83556132 (+)
DBA/2J MGP_DBA2J_G0034873
 protein coding gene Chr9:75577616-75595091 (+)
FVB/NJ MGP_FVBNJ_G0034815
 protein coding gene Chr9:74823219-74840674 (+)
LP/J MGP_LPJ_G0034954
 protein coding gene Chr9:78887952-78905303 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034856
 protein coding gene Chr9:84773785-84791269 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035573
 protein coding gene Chr9:77897300-77914764 (+)
PWK/PhJ MGP_PWKPhJ_G0033767
 protein coding gene Chr9:75811586-75827680 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033600
 protein coding gene Chr9:78133332-78150656 (+)
WSB/EiJ MGP_WSBEiJ_G0034175
 protein coding gene Chr9:77826211-77844551 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased sensitivity to oxidative stress, increased alanine and aspartate transaminase levels, increased susceptibility to bacterial infection, reduced litter size, and impaired glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1545
  • Tissues
    197
  • cDNA Data
    111
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14860 NCBI Gene Model | MGI Sequence Detail 17384 C57BL/6J ±  kb
    transcript NM_010357 RefSeq | MGI Sequence Detail 910 C57BL/6  
    polypeptide P24472 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
      1B48, 1GUK
    • EC
      2.5.1.18
    • InterPro Domains
      IPR003080 Glutathione S-transferase, alpha class
      IPR004046 Glutathione S-transferase, C-terminal
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR010987 Glutathione S-transferase, C-terminal-like
      IPR004045 Glutathione S-transferase, N-terminal
      IPR050213 Glutathione S-transferase superfamily
      IPR040079 Glutathione transferase family
      IPR036249 Thioredoxin-like superfamily
    • GlyGen
      P24472 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 114
      cDNA 111
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 12
      Gene Ontology 6
      Phenotypes 34
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory