Tagln2 MGI Mouse Gene Detail - MGI:1312985 - transgelin 2

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Tagln2 Gene Detail

Symbol

Tagln2
Name

transgelin 2
Synonyms

2700094C18Rik, Sm22B

Feature Type

protein coding gene
IDs

MGI:1312985
NCBI Gene: 21346
Alliance

gene page
Transcription Start Sites

28 TSS

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Sequence Map

Chr1:172327813-172334942 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.89 cM
Mapping Data

7 experiments

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SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1312985	protein coding gene	Chr1:172327614-172334947 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016790	protein coding gene	Chr1:178369255-178380036 (+)
A/J	MGP_AJ_G0016769	protein coding gene	Chr1:171080201-171089733 (+)
AKR/J	MGP_AKRJ_G0016735	protein coding gene	Chr1:176241481-176248807 (+)
BALB/cJ	MGP_BALBcJ_G0016730	protein coding gene	Chr1:171616400-171623935 (+)
C3H/HeJ	MGP_C3HHeJ_G0016554	protein coding gene	Chr1:176815432-176823667 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017192	protein coding gene	Chr1:184295407-184305052 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014898	protein coding gene	Chr1:162770948-162778232 (+)
CAST/EiJ	MGP_CASTEiJ_G0016134	protein coding gene	Chr1:176184233-176192829 (+)
CBA/J	MGP_CBAJ_G0016528	protein coding gene	Chr1:190841260-190853768 (+)
DBA/2J	MGP_DBA2J_G0016635	protein coding gene	Chr1:170003908-170011458 (+)
FVB/NJ	MGP_FVBNJ_G0016632	protein coding gene	Chr1:168260734-168269306 (+)
LP/J	MGP_LPJ_G0016706	protein coding gene	Chr1:179454058-179462036 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016659	protein coding gene	Chr1:198075683-198083033 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017228	protein coding gene	Chr1:176112202-176119543 (+)
PWK/PhJ	MGP_PWKPhJ_G0015920	protein coding gene	Chr1:169385435-169393662 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015702	protein coding gene	Chr1:175068340-175075598 (+)
WSB/EiJ	MGP_WSBEiJ_G0016196	protein coding gene	Chr1:176263987-176271933 (+)

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Human Ortholog

TAGLN2, transgelin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAGLN2, transgelin 2
Synonyms

HA1756
Links

HGNC:11554

NCBI Gene ID: 8407

neXtProt AC: NX_P37802

UniProt: P37802
Chr Location

1q23.2; chr1:159918107-159925507 (-) GRCh38

MGI Vertebrate Homology

Tagln2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAGLN2
Gene Tree

Tagln2

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

22
Targeted

1
Genomic Mutations

2 involving Tagln2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display abnormalities in T cell physiology including cytotoxicity.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

71
cDNA Data

243
Literature Summary

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tagln2

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All Sequences

48
RefSeq

2
UniProt

2
CCDS

CCDS35784.1

Ensembl

ENSMUSG00000026547 (Evidence)
NCBI Gene

21346

Representative Sequences				Length	Strain/Species	Flank
	genomic	21346	NCBI Gene Model \| MGI Sequence Detail	7130	C57BL/6J	± kb
	transcript	NM_178598	RefSeq \| MGI Sequence Detail	1382	ZRU/MplStud
	polypeptide	Q9WVA4	UniProt \| EBI \| MGI Sequence Detail	199	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016040 transgelin-2

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR050606 Calponin-like

IPR000557 Calponin repeat

IPR036872 CH domain superfamily

IPR003096 Smooth muscle protein/calponin
GlyGen

Q9WVA4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 267

Genomic 23

cDNA 243

Primer pair 1

Microarray probesets 6

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MGI:1925645

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Summaries

All 54

Developmental Gene Expression 11

Gene Ontology 3

Phenotypes 13
Earliest

J:49043 Stanier P, et al., Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship. Genomics. 1998 Jul 1;51(1):144-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tagln2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10207	Chr1:172327425-172327436 (+)	-382 bp
Tssr10208	Chr1:172327454-172327479 (+)	-346 bp
Tssr10209	Chr1:172327483-172327499 (+)	-322 bp
Tssr10210	Chr1:172327515-172327546 (+)	-282 bp
Tssr10211	Chr1:172327569-172327580 (+)	-238 bp
Tssr10212	Chr1:172327808-172327815 (+)	-1 bp
Tssr10213	Chr1:172327820-172327822 (+)	8 bp
Tssr10214	Chr1:172327832-172327855 (+)	31 bp
Tssr10215	Chr1:172328769-172328806 (+)	975 bp
Tssr10216	Chr1:172328807-172328824 (+)	1,003 bp
Tssr10217	Chr1:172329511-172329556 (+)	1,721 bp
Tssr10218	Chr1:172330147-172330159 (+)	2,340 bp
Tssr10219	Chr1:172332830-172332867 (+)	5,036 bp
Tssr10220	Chr1:172333318-172333338 (+)	5,515 bp
Tssr10221	Chr1:172333360-172333373 (+)	5,554 bp
Tssr10222	Chr1:172333446-172333466 (+)	5,643 bp
Tssr10223	Chr1:172333793-172333834 (+)	6,001 bp
Tssr10224	Chr1:172334139-172334151 (+)	6,332 bp
Tssr10225	Chr1:172334178-172334190 (+)	6,371 bp
Tssr10226	Chr1:172334191-172334209 (+)	6,387 bp
Tssr10227	Chr1:172334232-172334271 (+)	6,439 bp
Tssr10228	Chr1:172334284-172334302 (+)	6,480 bp
Tssr10229	Chr1:172334334-172334352 (+)	6,530 bp
Tssr10230	Chr1:172334355-172334417 (+)	6,573 bp
Tssr10231	Chr1:172334418-172334427 (+)	6,610 bp
Tssr10232	Chr1:172334462-172334491 (+)	6,664 bp
Tssr10233	Chr1:172334493-172334526 (+)	6,697 bp
Tssr10234	Chr1:172334552-172334564 (+)	6,745 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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