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Fzd9 Gene Detail
Summary
  • Symbol
    Fzd9
  • Name
    frizzled class receptor 9
  • Synonyms
    frizzled 9, Fz9, mfz9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313278
    NCBI Gene: 14371
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135277792-135279901 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.08 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313278
 protein coding gene Chr5:135277792-135280084 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030178
 protein coding gene Chr5:139755923-139758215 (-)
A/J MGP_AJ_G0030146
 protein coding gene Chr5:133780461-133782753 (-)
AKR/J MGP_AKRJ_G0030079
 protein coding gene Chr5:138126820-138129112 (-)
BALB/cJ MGP_BALBcJ_G0030156
 protein coding gene Chr5:135135577-135137869 (-)
C3H/HeJ MGP_C3HHeJ_G0029872
 protein coding gene Chr5:138686814-138689106 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030609
 protein coding gene Chr5:144984530-144986822 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027832
 protein coding gene Chr5:128080938-128083232 (-)
CAST/EiJ MGP_CASTEiJ_G0029281
 protein coding gene Chr5:138106761-138109053 (-)
CBA/J MGP_CBAJ_G0029842
 protein coding gene Chr5:150661975-150664267 (-)
DBA/2J MGP_DBA2J_G0029993
 protein coding gene Chr5:133678419-133680711 (-)
FVB/NJ MGP_FVBNJ_G0029948
 protein coding gene Chr5:132812355-132814647 (-)
LP/J MGP_LPJ_G0030081
 protein coding gene Chr5:140200447-140202739 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029980
 protein coding gene Chr5:153668418-153670710 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030649
 protein coding gene Chr5:137873270-137875562 (-)
PWK/PhJ MGP_PWKPhJ_G0028996
 protein coding gene Chr5:132722780-132725072 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028831
 protein coding gene Chr5:135440779-135443067 (-)
WSB/EiJ MGP_WSBEiJ_G0029355
 protein coding gene Chr5:138620298-138622590 (-)



Homology
more
  • Human Ortholog
    FZD9, frizzled class receptor 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD9, frizzled class receptor 9
  • Synonyms
    CD349, FZD3
  • Links
    NCBI Gene ID: 8326
    neXtProt AC: NX_O00144
    UniProt: O00144

  • Chr Location
    7q11.23; chr7:73433778-73436120 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fzd9 mouse models

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 3 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one allele exhibit immune system abnormalities while another null allele causes neurological abnormalities. A third null mutation results in growth retardation and abnormalities in bone mineralization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1307
  • Tissues
    267
  • cDNA Data
    17
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14371 NCBI Gene Model | MGI Sequence Detail 2110 C57BL/6J ±  kb
    transcript NM_010246 RefSeq | MGI Sequence Detail 2110 ZRU/MplStud  
    polypeptide Q9R216 UniProt | EBI | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 4
      cDNA 21
      Primer pair 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 42
      Diseases 5
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:49924 Wang YK, et al., Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics. 1999 Apr 15;57(2):235-48
    • Latest
      J:337436 Abdalla N, et al., Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory