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Vezf1 Gene Detail
Summary
  • Symbol
    Vezf1
  • Name
    vascular endothelial zinc finger 1
  • Synonyms
    db1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313291
    NCBI Gene: 22344
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:87959105-87975555 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313291
 protein coding gene Chr11:87959084-87975555 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018920
 protein coding gene Chr11:89750890-89767349 (+)
A/J MGP_AJ_G0018888
 protein coding gene Chr11:86272894-86289359 (+)
AKR/J MGP_AKRJ_G0018858
 protein coding gene Chr11:88894118-88910580 (+)
BALB/cJ MGP_BALBcJ_G0018861
 protein coding gene Chr11:86691034-86707490 (+)
C3H/HeJ MGP_C3HHeJ_G0018675
 protein coding gene Chr11:88915548-88932012 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019313
 protein coding gene Chr11:92479861-92496311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016944
 protein coding gene Chr11:83294809-83311280 (+)
CAST/EiJ MGP_CASTEiJ_G0018230
 protein coding gene Chr11:89605659-89622160 (+)
CBA/J MGP_CBAJ_G0018646
 protein coding gene Chr11:96412293-96428753 (+)
DBA/2J MGP_DBA2J_G0018754
 protein coding gene Chr11:85837536-85853996 (+)
FVB/NJ MGP_FVBNJ_G0018743
 protein coding gene Chr11:85335207-85353121 (+)
LP/J MGP_LPJ_G0018824
 protein coding gene Chr11:90264776-90281232 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018770
 protein coding gene Chr11:96420860-96437317 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019353
 protein coding gene Chr11:89114673-89138074 (+)
PWK/PhJ MGP_PWKPhJ_G0018000
 protein coding gene Chr11:86681065-86697755 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017791
 protein coding gene Chr11:88681805-88699742 (+)
WSB/EiJ MGP_WSBEiJ_G0018279
 protein coding gene Chr11:89004899-89022609 (+)



Homology
more
  • Human Ortholog
    VEZF1, vascular endothelial zinc finger 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VEZF1, vascular endothelial zinc finger 1
  • Synonyms
    CMD1OO, DB1, ZNF161
  • Links
    NCBI Gene ID: 7716
    neXtProt AC: NX_Q14119
    UniProt: Q14119

  • Chr Location
    17q22; chr17:57971547-57988259 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VEZF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die at midgestation due to angiogenic remodeling defects and loss of vascular integrity leading to hemorrhaging in the head, heart and trunk. One fifth of heterozygous null embryos show lymphatic hypervascularization associated with hemorrhaging and edema in the jugular region.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    937
  • Tissues
    202
  • cDNA Data
    144
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018377 Ensembl Gene Model | MGI Sequence Detail 16451 C57BL/6J ±  kb
    transcript ENSMUST00000018521 Ensembl | MGI Sequence Detail 4583 Not Applicable  
    polypeptide ENSMUSP00000018521 Ensembl | MGI Sequence Detail 518 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR050527 Snail/Krueppel C2H2-type Zinc-finger
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    • GlyGen
      Q5SXC4 4 sites, 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 147
      Primer pair 3
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144299, MGI:2144482
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:223501 Gerald D, et al., RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription. Nat Commun. 2013;4:2824
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory