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Hipk2 Gene Detail
Summary
  • Symbol
    Hipk2
  • Name
    homeodomain interacting protein kinase 2
  • Synonyms
    1110014O20Rik, B230339E18Rik, Stank
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314872
    NCBI Gene: 15258
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:38671325-38853099 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 17.85 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3567 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314872
 protein coding gene Chr6:38664447-38853236 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030591
 protein coding gene Chr6:37035849-37219126 (-)
A/J MGP_AJ_G0030564
 protein coding gene Chr6:35410208-35593197 (-)
AKR/J MGP_AKRJ_G0030491
 protein coding gene Chr6:36547147-36733613 (-)
BALB/cJ MGP_BALBcJ_G0030574
 protein coding gene Chr6:35628346-35807474 (-)
C3H/HeJ MGP_C3HHeJ_G0030287
 protein coding gene Chr6:36560688-36741388 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031028
 protein coding gene Chr6:37952019-38138504 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028240
 protein coding gene Chr6:33318331-33498701 (-)
CAST/EiJ MGP_CASTEiJ_G0029689
 protein coding gene Chr6:36444194-36641424 (-)
CBA/J MGP_CBAJ_G0030265
 protein coding gene Chr6:39441034-39632750 (-)
DBA/2J MGP_DBA2J_G0030409
 protein coding gene Chr6:35231338-35411953 (-)
FVB/NJ MGP_FVBNJ_G0030363
 protein coding gene Chr6:35020524-35202752 (-)
LP/J MGP_LPJ_G0030496
 protein coding gene Chr6:37066760-37249431 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030399
 protein coding gene Chr6:41820234-42013619 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031058
 protein coding gene Chr6:36477511-36662159 (-)
PWK/PhJ MGP_PWKPhJ_G0029403
 protein coding gene Chr6:34904143-35086337 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029239
 protein coding gene Chr6:36193521-36384792 (-)
WSB/EiJ MGP_WSBEiJ_G0029765
 protein coding gene Chr6:36422233-36605954 (-)



Homology
more
  • Human Ortholog
    HIPK2, homeodomain interacting protein kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIPK2, homeodomain interacting protein kinase 2
  • Synonyms
    PRO0593
  • Links
    NCBI Gene ID: 28996
    neXtProt AC: NX_Q9H2X6
    UniProt: Q9H2X6

  • Chr Location
    7q34; chr7:139561570-139777998 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased apoptosis and increased neuron numbers in the trigeminal ganglion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    127
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    898
  • Tissues
    173
  • cDNA Data
    15
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061436 Ensembl Gene Model | MGI Sequence Detail 181775 C57BL/6J ±  kb
    transcript ENSMUST00000161779 Ensembl | MGI Sequence Detail 7684 Not Applicable  
    polypeptide ENSMUSP00000124133 Ensembl | MGI Sequence Detail 1196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 16
      Primer pair 4
      Other 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1915852, MGI:1929609, MGI:2443252
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 19
      Gene Ontology 25
      Phenotypes 39
    • Earliest
      J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
    • Latest
      J:357744 Sozzi S, et al., Inactivation of HIPK2 attenuates KRAS(G12D) activity and prevents pancreatic tumorigenesis. J Exp Clin Cancer Res. 2024 Sep 28;43(1):265
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory