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Men1 Gene Detail
Summary
  • Symbol
    Men1
  • Name
    multiple endocrine neoplasia 1
  • Synonyms
    menin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316736
    NCBI Gene: 17283
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6385009-6390921 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.45 cM, cytoband A
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316736
 protein coding gene Chr19:6385009-6390924 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024759
 protein coding gene Chr19:3384282-3390194 (+)
A/J MGP_AJ_G0024725
 protein coding gene Chr19:3200287-3206199 (+)
AKR/J MGP_AKRJ_G0024698
 protein coding gene Chr19:3295841-3301753 (+)
BALB/cJ MGP_BALBcJ_G0024725
 protein coding gene Chr19:3198463-3204375 (+)
C3H/HeJ MGP_C3HHeJ_G0024493
 protein coding gene Chr19:3317513-3323425 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025171
 protein coding gene Chr19:3437709-3443621 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022605
 protein coding gene Chr19:3121912-3127728 (+)
CAST/EiJ MGP_CASTEiJ_G0023965
 protein coding gene Chr19:3340020-3345932 (+)
CBA/J MGP_CBAJ_G0024465
 protein coding gene Chr19:3611713-3617621 (+)
DBA/2J MGP_DBA2J_G0024592
 protein coding gene Chr19:3189396-3195304 (+)
FVB/NJ MGP_FVBNJ_G0024558
 protein coding gene Chr19:3203929-3209841 (+)
LP/J MGP_LPJ_G0024678
 protein coding gene Chr19:3351178-3357090 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024587
 protein coding gene Chr19:3432305-3438217 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025219
 protein coding gene Chr19:3322167-3328079 (+)
PWK/PhJ MGP_PWKPhJ_G0023711
 protein coding gene Chr19:3221305-3227212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023516
 protein coding gene Chr19:3282986-3288879 (+)
WSB/EiJ MGP_WSBEiJ_G0024027
 protein coding gene Chr19:3337103-3343015 (+)



Homology
more
  • Human Ortholog
    MEN1, menin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEN1, menin 1
  • Synonyms
    MEAI, SCG2
  • Links
    NCBI Gene ID: 4221
    neXtProt AC: NX_O00255
    UniProt: O00255

  • Chr Location
    11q13.1; chr11:64803510-64811294 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Men1 mouse models; 6 with human MEN1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 7 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    117 phenotypes from 12 alleles in 18 genetic backgrounds
    26 phenotypes from multigenic genotypes
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die at embryonic day 11.5-13.5 with reduced size, edema, open neural tube and defects of the nervous system, heart and liver. Heterozygotes develop tumors of the pancreas, parathyroid, thyroid, adrenal and pituitary.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    148
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    59
  • cDNA Data
    30
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024947 Ensembl Gene Model | MGI Sequence Detail 5913 C57BL/6J ±  kb
    transcript ENSMUST00000113502 Ensembl | MGI Sequence Detail 2652 Not Applicable  
    polypeptide ENSMUSP00000109130 Ensembl | MGI Sequence Detail 617 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 8
      cDNA 31
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147685
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 20
      Diseases 6
      Gene Ontology 30
      Phenotypes 110
    • Earliest
      J:51201 Stewart C, et al., Characterization of the mouse Men1 gene and its expression during development. Oncogene. 1998 Nov 12;17(19):2485-93
    • Latest
      J:347360 Fuentes ME, et al., Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice. Sci Rep. 2024 Apr 12;14(1):8510
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory