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St3gal4 Gene Detail
Summary
  • Symbol
    St3gal4
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 4
  • Synonyms
    Siat4c, ST3Gal IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316743
    NCBI Gene: 20443
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:34957872-35028160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 19.36 cM, cytoband A5.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1399 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316743
 protein coding gene Chr9:34957872-35030564 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034528
 protein coding gene Chr9:32860536-32917436 (-)
A/J MGP_AJ_G0034506
 protein coding gene Chr9:32016846-32067871 (-)
AKR/J MGP_AKRJ_G0034432
 protein coding gene Chr9:32730464-32785857 (-)
BALB/cJ MGP_BALBcJ_G0034497
 protein coding gene Chr9:31932180-31982935 (-)
C3H/HeJ MGP_C3HHeJ_G0034209
 protein coding gene Chr9:33068777-33123020 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035018
 protein coding gene Chr9:33968664-34033300 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031948
 protein coding gene Chr9:30707899-30756850 (-)
CAST/EiJ MGP_CASTEiJ_G0033532
 protein coding gene Chr9:32958936-33016067 (-)
CBA/J MGP_CBAJ_G0034183
 protein coding gene Chr9:35118508-35176426 (-)
DBA/2J MGP_DBA2J_G0034340
 protein coding gene Chr9:31994804-32048376 (-)
FVB/NJ MGP_FVBNJ_G0034283
 protein coding gene Chr9:31410973-31463225 (-)
LP/J MGP_LPJ_G0034426
 protein coding gene Chr9:33111983-33169137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034327
 protein coding gene Chr9:36698048-36749898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035038
 protein coding gene Chr9:32688140-32739824 (-)
PWK/PhJ MGP_PWKPhJ_G0033237
 protein coding gene Chr9:31981891-32032545 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033072
 protein coding gene Chr9:32832528-32884921 (-)
WSB/EiJ MGP_WSBEiJ_G0033647
 protein coding gene Chr9:32454942-32506401 (-)



Homology
more
  • Human Ortholog
    ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4
  • Synonyms
    CGS23, gal-NAc6S, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalA.2, ST3GalIV, ST-4, STZ
  • Links
    NCBI Gene ID: 6484
    neXtProt AC: NX_Q11206
    UniProt: Q11206

  • Chr Location
    11q24.2; chr11:126355640-126440344 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show thrombocytopenia, altered platelet physiology, increased bleeding times, and abnormal leukocyte migration. Homozygotes for a different null allele fail to develop seizures in response to kindling, and show anxiety-like behaviors and altered sleep patterns.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    115
  • cDNA Data
    57
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20443 NCBI Gene Model | MGI Sequence Detail 70289 C57BL/6J ±  kb
transcript NM_009178 RefSeq | MGI Sequence Detail 2097 C57BL/6  
polypeptide Q91Y74 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 58
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 67
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 33
  • Earliest
    J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
  • Latest
    J:335682 Pisa E, et al., Long-term consequences of reduced availability and compensatory supplementation of sialylated HMOs on cognitive capabilities. Front Cell Neurosci. 2023;17:1091890
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory