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Entpd5 Gene Detail
Summary
  • Symbol
    Entpd5
  • Name
    ectonucleoside triphosphate diphosphohydrolase 5
  • Synonyms
    Cd39l4, ER-UDPase, mNTPase, NTPDase-5, NTPDase5, Pcph
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321385
    NCBI Gene: 12499
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84420649-84455803 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.18 cM, cytoband E
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1092 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321385
 protein coding gene Chr12:84420631-84455803 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019935
 protein coding gene Chr12:85077493-85114455 (-)
A/J MGP_AJ_G0019892
 protein coding gene Chr12:81857592-81893009 (-)
AKR/J MGP_AKRJ_G0019868
 protein coding gene Chr12:84075701-84110282 (-)
BALB/cJ MGP_BALBcJ_G0019872
 protein coding gene Chr12:82191077-82226018 (-)
C3H/HeJ MGP_C3HHeJ_G0019678
 protein coding gene Chr12:84538964-84575328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020323
 protein coding gene Chr12:87522876-87570658 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017941
 protein coding gene Chr12:78759885-78793725 (-)
CAST/EiJ MGP_CASTEiJ_G0019227
 protein coding gene Chr12:79492087-79530861 (-)
CBA/J MGP_CBAJ_G0019649
 protein coding gene Chr12:90903884-90946261 (-)
DBA/2J MGP_DBA2J_G0019764
 protein coding gene Chr12:81386643-81422003 (-)
FVB/NJ MGP_FVBNJ_G0019750
 protein coding gene Chr12:80338123-80373810 (-)
LP/J MGP_LPJ_G0019836
 protein coding gene Chr12:84955663-84995453 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019789
 protein coding gene Chr12:93818817-93858065 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020357
 protein coding gene Chr12:83669564-83704136 (-)
PWK/PhJ MGP_PWKPhJ_G0018991
 protein coding gene Chr12:75874335-75911000 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018786
 protein coding gene Chr12:78158246-78196755 (-)
WSB/EiJ MGP_WSBEiJ_G0019279
 protein coding gene Chr12:84382126-84419347 (-)



Homology
more
  • Human Ortholog
    ENTPD5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENTPD5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
  • Synonyms
    CD39L4, NTPDase-5, PCPH
  • Links
    NCBI Gene ID: 957
    neXtProt AC: NX_O75356
    UniProt: O75356

  • Chr Location
    14q24.3; chr14:73955329-74019399 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    984
  • Tissues
    252
  • cDNA Data
    97
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12499 NCBI Gene Model | MGI Sequence Detail 35155 C57BL/6J ±  kb
    transcript NM_001026214 RefSeq | MGI Sequence Detail 4987 Not Specified  
    polypeptide Q9WUZ9 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007096 nucleoside diphosphate phosphatase ENTPD5
      (term hierarchy)
    • EC
      3.6.1.6
    • InterPro Domains
      IPR000407 Nucleoside phosphatase GDA1/CD39
    • GlyGen
      Q9WUZ9 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 1
      cDNA 100
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2144773, MGI:2144919
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:45879 Chadwick BP, et al., cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases. Mamm Genome. 1998 Feb;9(2):162-4
    • Latest
      J:302767 Walsh J, et al., Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications. J Proteomics. 2014 Aug 28;108:171-87
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory