About   Help   FAQ
Ly86 Gene Detail
Summary
  • Symbol
    Ly86
  • Name
    lymphocyte antigen 86
  • Synonyms
    MD-1, MD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321404
    NCBI Gene: 17084
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:37529276-37603012 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 14.70 cM
Strain
Comparison
more
  • SNPs within 2kb
    2517 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321404
 protein coding gene Chr13:37529184-37603012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020465
 protein coding gene Chr13:35600913-35679197 (+)
A/J MGP_AJ_G0020419
 protein coding gene Chr13:34506504-34582348 (+)
AKR/J MGP_AKRJ_G0020397
 protein coding gene Chr13:35411510-35486436 (+)
BALB/cJ MGP_BALBcJ_G0020415
 protein coding gene Chr13:34609313-34679434 (+)
C3H/HeJ MGP_C3HHeJ_G0020214
 protein coding gene Chr13:35248629-35319610 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020848
 protein coding gene Chr13:36783916-36867090 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018435
 protein coding gene Chr13:32696382-32763994 (+)
CAST/EiJ MGP_CASTEiJ_G0019729
 protein coding gene Chr13:34971456-35044910 (+)
CBA/J MGP_CBAJ_G0020175
 protein coding gene Chr13:38358328-38431878 (+)
DBA/2J MGP_DBA2J_G0020297
 protein coding gene Chr13:34033722-34107686 (+)
FVB/NJ MGP_FVBNJ_G0020276
 protein coding gene Chr13:33565655-33637619 (+)
LP/J MGP_LPJ_G0020372
 protein coding gene Chr13:35859492-35929858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020306
 protein coding gene Chr13:38509642-38584789 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020891
 protein coding gene Chr13:34968626-35045518 (+)
PWK/PhJ MGP_PWKPhJ_G0019484
 protein coding gene Chr13:34136089-34211036 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019315
 protein coding gene Chr13:33647464-33719124 (+)
WSB/EiJ MGP_WSBEiJ_G0019791
 protein coding gene Chr13:35323408-35396254 (+)



Homology
more
  • Human Ortholog
    LY86, lymphocyte antigen 86
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LY86, lymphocyte antigen 86
  • Synonyms
    dJ80N2.1, MD-1, MD1, MMD-1
  • Links
    NCBI Gene ID: 9450
    neXtProt AC: NX_O95711
    UniProt: O95711

  • Chr Location
    6p25.1; chr6:6588108-6654983 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    17
  • cDNA Data
    32
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17084 NCBI Gene Model | MGI Sequence Detail 73737 C57BL/6J ±  kb
    transcript NM_010745 RefSeq | MGI Sequence Detail 919 C57BL/6  
    polypeptide O88188 UniProt | EBI | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 32
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:344350 Griffin EN, et al., RREB1 regulates neuronal proteostasis and the microtubule network. Sci Adv. 2024 Jan 12;10(2):eadh3929
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory