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Slfn3 Gene Detail
Summary
  • Symbol
    Slfn3
  • Name
    schlafen 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329005
    NCBI Gene: 20557
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83082156-83105980 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.30 cM, cytoband B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329005
 protein coding gene Chr11:83082156-83105980 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018842
 protein coding gene Chr11:84505169-84533069 (+)
A/J MGP_AJ_G0018809
 protein coding gene Chr11:81300650-81324242 (+)
AKR/J MGP_AKRJ_G0018779
 protein coding gene Chr11:83706352-83730918 (+)
BALB/cJ MGP_BALBcJ_G0018782
 protein coding gene Chr11:81706246-81727334 (+)
C3H/HeJ MGP_C3HHeJ_G0018596
 protein coding gene Chr11:83756183-83785470 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019234
 protein coding gene Chr11:87096793-87127099 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016868
 protein coding gene Chr11:78088059-78090848 (+)
CAST/EiJ MGP_CASTEiJ_G0018151
 protein coding gene Chr11:84380908-84383550 (+)
CBA/J MGP_CBAJ_G0018567
 protein coding gene Chr11:90877245-90905813 (+)
DBA/2J MGP_DBA2J_G0018675
 protein coding gene Chr11:80864447-80890651 (+)
FVB/NJ MGP_FVBNJ_G0018664
 protein coding gene Chr11:80381911-80403773 (+)
LP/J MGP_LPJ_G0018745
 protein coding gene Chr11:85041905-85119498 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018691
 protein coding gene Chr11:91040308-91066375 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019274
 protein coding gene Chr11:83984512-84009732 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0017712
 protein coding gene Chr11:83532827-83558514 (+)
WSB/EiJ MGP_WSBEiJ_G0018202
 protein coding gene Chr11:83853803-83878886 (+)



Homology
more
  • Human Ortholog
    SLFN12, schlafen family member 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLFN12, schlafen family member 12
  • Synonyms
    SLFN3
  • Links
    NCBI Gene ID: 55106
    neXtProt AC: NX_Q8IYM2
    UniProt: Q8IYM2

  • Chr Location
    17q12; chr17:35409465-35433475 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Mice homozygous for a null allele exhibit normal immune cell populations and MOG-induced experimental autoimmune encephalitis development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    94
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20557 NCBI Gene Model | MGI Sequence Detail 23825 C57BL/6J ±  kb
transcript NM_011409 RefSeq | MGI Sequence Detail 1834 Not Specified  
polypeptide NP_035539 RefSeq | MGI Sequence Detail 517 Not Specified  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR031450 Poxin-Schlafen/Schlafen-like, N-terminal domain
    IPR007421 Schlafen, AlbA_2 domain
    IPR038461 Schlafen, AlbA_2 domain superfamily
    IPR029684 Schlafen family
    IPR048729 Schlafen, GTPase-like domain
Molecular
Reagents
less
  • All nucleic 10
    Genomic 1
    cDNA 8
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:344682 Vomhof-DeKrey EE, et al., Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in lung, stomach, cecum, kidney, and proximal colon differentiation markers and Slfn family members expression levels. Biochem Biophys Rep. 2023 Dec;36:101552
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory