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Msh5 Gene Detail
Summary
  • Symbol
    Msh5
  • Name
    mutS homolog 5
  • Synonyms
    G7, Mut5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329021
    NCBI Gene: 17687
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35247581-35265721 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.57 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329021
 protein coding gene Chr17:35247581-35267842 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023608
 protein coding gene Chr17:35161204-35183095 (-)
A/J MGP_AJ_G0023568
 protein coding gene Chr17:34002760-34020743 (-)
AKR/J MGP_AKRJ_G0023536
 protein coding gene Chr17:34474408-34491738 (-)
BALB/cJ MGP_BALBcJ_G0023574
 protein coding gene Chr17:34133085-34152180 (-)
C3H/HeJ MGP_C3HHeJ_G0023335
 protein coding gene Chr17:34868610-34887260 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024013
 protein coding gene Chr17:36503804-36522858 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021494
 protein coding gene Chr17:31769284-31787384 (-)
CAST/EiJ MGP_CASTEiJ_G0022832
 protein coding gene Chr17:34870896-34890650 (-)
CBA/J MGP_CBAJ_G0023313
 protein coding gene Chr17:38013013-38030671 (-)
DBA/2J MGP_DBA2J_G0023441
 protein coding gene Chr17:33322544-33341080 (-)
FVB/NJ MGP_FVBNJ_G0023408
 protein coding gene Chr17:33157760-33176620 (-)
LP/J MGP_LPJ_G0023518
 protein coding gene Chr17:35489901-35509524 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023430
 protein coding gene Chr17:36944928-36964915 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024058
 protein coding gene Chr17:34697017-34714416 (-)
PWK/PhJ MGP_PWKPhJ_G0022579
 protein coding gene Chr17:32153601-32173743 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022399
 protein coding gene Chr17:32706089-32726579 (-)
WSB/EiJ MGP_WSBEiJ_G0022895
 protein coding gene Chr17:34810019-34829406 (-)



Homology
more
  • Human Ortholog
    MSH5, mutS homolog 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSH5, mutS homolog 5
  • Synonyms
    G7, MUTSH5, NG23, POF13, SPGF74
  • Links
    NCBI Gene ID: 4439
    neXtProt AC: NX_O43196
    UniProt: O43196

  • Chr Location
    6p21.33; chr6:31739677-31762676 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Msh5 mouse models; 3 with human MSH5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit disrupted chromosome pairing in meiosis I resulting in cell death and sterility. In males, testes size is reduced, and in females, there is a total loss of ovarian structure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    12
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007035 Ensembl Gene Model | MGI Sequence Detail 18141 C57BL/6J ±  kb
    transcript ENSMUST00000007250 Ensembl | MGI Sequence Detail 2886 Not Applicable  
    polypeptide ENSMUSP00000007250 Ensembl | MGI Sequence Detail 833 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000010669 MutS protein homolog 5
      (term hierarchy)
    • InterPro Domains
      IPR011184 DNA mismatch repair Msh2-type
      IPR045076 DNA mismatch repair MutS family
      IPR007696 DNA mismatch repair protein MutS, core
      IPR036187 DNA mismatch repair protein MutS, core domain superfamily
      IPR000432 DNA mismatch repair protein MutS, C-terminal
      IPR017261 DNA mismatch repair protein MutS/MSH
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 6
      cDNA 15
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:51921 Edelmann W, et al., Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet. 1999 Jan;21(1):123-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory