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Papss2 Gene Detail
Summary
  • Symbol
    Papss2
  • Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 2
  • Synonyms
    1810018P12Rik, Atpsk2, Sk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330223
    NCBI Gene: 23972
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:32573190-32644587 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 27.46 cM
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2334 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330223
 protein coding gene Chr19:32573072-32644587 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025041
 protein coding gene Chr19:31259770-31309242 (+)
A/J MGP_AJ_G0025018
 protein coding gene Chr19:29704110-29751018 (+)
AKR/J MGP_AKRJ_G0024986
 protein coding gene Chr19:30745493-30793162 (+)
BALB/cJ MGP_BALBcJ_G0025017
 protein coding gene Chr19:29763330-29811612 (+)
C3H/HeJ MGP_C3HHeJ_G0024773
 protein coding gene Chr19:30741800-30790511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025458
 protein coding gene Chr19:32139431-32190916 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022877
 protein coding gene Chr19:29612430-29659549 (+)
CAST/EiJ MGP_CASTEiJ_G0024244
 protein coding gene Chr19:30644735-30697651 (+)
CBA/J MGP_CBAJ_G0024751
 protein coding gene Chr19:33631630-33687936 (+)
DBA/2J MGP_DBA2J_G0024883
 protein coding gene Chr19:29628197-29676350 (+)
FVB/NJ MGP_FVBNJ_G0024845
 protein coding gene Chr19:29455771-29503313 (+)
LP/J MGP_LPJ_G0024968
 protein coding gene Chr19:31259974-31321526 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024872
 protein coding gene Chr19:33481866-33540793 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025513
 protein coding gene Chr19:30803409-30852571 (+)
PWK/PhJ MGP_PWKPhJ_G0023992
 protein coding gene Chr19:29325765-29374576 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023796
 protein coding gene Chr19:30123538-30171299 (+)
WSB/EiJ MGP_WSBEiJ_G0024310
 protein coding gene Chr19:30831300-30880527 (+)



Homology
more
  • Human Ortholog
    PAPSS2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAPSS2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
  • Synonyms
    ATPSK2, BCYM4, SK2
  • Links
    NCBI Gene ID: 9060
    neXtProt AC: NX_O95340
    UniProt: O95340

  • Chr Location
    10q23.2-q23.31; chr10:87659613-87747705 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Papss2 mouse models; 1 with human PAPSS2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutation s in this gene display delayed growth and shorter limbs and other abnormalities in bone formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1224
  • Tissues
    294
  • cDNA Data
    67
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024899 Ensembl Gene Model | MGI Sequence Detail 71398 C57BL/6J ±  kb
    transcript ENSMUST00000025833 Ensembl | MGI Sequence Detail 3635 Not Applicable  
    polypeptide ENSMUSP00000025833 Ensembl | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      Genomic 3
      cDNA 67
      Primer pair 6
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1582, MGI:1921420, MGI:2147481, MGI:88171
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 13
      Phenotypes 33
    • Earliest
      J:5109 Lane PW, et al., Three recessive mutations producing disproportionate dwarfing in mice: achondroplasia, brachymorphic, and stubby. J Hered. 1968 Sep-Oct;59(5):300-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory