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Magoh Gene Detail
Summary
  • Symbol
    Magoh
  • Name
    mago homolog, exon junction complex core component
  • Synonyms
    Mago-m, Mos2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330312
    NCBI Gene: 17149
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:107736952-107744621 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.18 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330312
 protein coding gene Chr4:107736952-107744621 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028543
 protein coding gene Chr4:108582802-108590448 (+)
A/J MGP_AJ_G0028506
 protein coding gene Chr4:104683142-104690801 (+)
AKR/J MGP_AKRJ_G0028453
 protein coding gene Chr4:107257334-107265203 (+)
BALB/cJ MGP_BALBcJ_G0028525
 protein coding gene Chr4:104883559-104891213 (+)
C3H/HeJ MGP_C3HHeJ_G0028239
 protein coding gene Chr4:107999849-108007443 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028965
 protein coding gene Chr4:112472575-112480964 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026256
 protein coding gene Chr4:99993822-100001528 (+)
CAST/EiJ MGP_CASTEiJ_G0027675
 protein coding gene Chr4:105831040-105838734 (+)
CBA/J MGP_CBAJ_G0028208
 protein coding gene Chr4:116115070-116122875 (+)
DBA/2J MGP_DBA2J_G0028356
 protein coding gene Chr4:104305990-104313609 (+)
FVB/NJ MGP_FVBNJ_G0028324
 protein coding gene Chr4:103175859-103183662 (+)
LP/J MGP_LPJ_G0028457
 protein coding gene Chr4:108780499-108788194 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028350
 protein coding gene Chr4:121387317-121395814 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029001
 protein coding gene Chr4:107501500-107509197 (+)
PWK/PhJ MGP_PWKPhJ_G0027401
 protein coding gene Chr4:102555995-102563982 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027225
 protein coding gene Chr4:104877826-104885446 (+)
WSB/EiJ MGP_WSBEiJ_G0027756
 protein coding gene Chr4:107681913-107690793 (+)



Homology
more
  • Human Ortholog
    MAGOH, mago homolog, exon junction complex subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGOH, mago homolog, exon junction complex subunit
  • Synonyms
    MAGOH1, MAGOHA
  • Links
    NCBI Gene ID: 4116
    neXtProt AC: NX_P61326
    UniProt: P61326

  • Chr Location
    1p32.3; chr1:53226900-53238518 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 5 alleles in 7 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutation in this gene is embryonic lethal and heterozygous mice are postnatal lethal with incomplete penetrance with reduced body size and microcephaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    13
  • cDNA Data
    67
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17149 NCBI Gene Model | MGI Sequence Detail 7670 C57BL/6J ±  kb
    transcript NM_001282737 RefSeq | MGI Sequence Detail 692 ZRU/MplStud  
    polypeptide P61327 UniProt | EBI | MGI Sequence Detail 146 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR004023 Mago nashi protein
      IPR036605 Mago nashi superfamily
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 67
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3822488
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:113667 Newmark PA, et al., mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila. Development. 1997 Aug;124(16):3197-207
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory