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Atp10a Gene Detail
Summary
  • Symbol
    Atp10a
  • Name
    ATPase, class V, type 10A
  • Synonyms
    Atp10c, pfatp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330809
    NCBI Gene: 11982
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:58305914-58479168 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 33.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330809
 protein coding gene Chr7:58305896-58479783 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032321
 protein coding gene Chr7:59485674-59664160 (+)
A/J MGP_AJ_G0032300
 protein coding gene Chr7:58604854-58777972 (+)
AKR/J MGP_AKRJ_G0032236
 protein coding gene Chr7:59897410-60079035 (+)
BALB/cJ MGP_BALBcJ_G0032312
 protein coding gene Chr7:58155771-58330971 (+)
C3H/HeJ MGP_C3HHeJ_G0032025
 protein coding gene Chr7:60287306-60465655 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032805
 protein coding gene Chr7:62187444-62370624 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029812
 protein coding gene Chr7:61076082-61251055 (+)
CAST/EiJ MGP_CASTEiJ_G0031354
 protein coding gene Chr7:51459249-51641749 (+)
CBA/J MGP_CBAJ_G0031990
 protein coding gene Chr7:64341126-64536198 (+)
DBA/2J MGP_DBA2J_G0032147
 protein coding gene Chr7:57544489-57719554 (+)
FVB/NJ MGP_FVBNJ_G0032101
 protein coding gene Chr7:57514296-57693862 (+)
LP/J MGP_LPJ_G0032228
 protein coding gene Chr7:60613940-60794489 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032138
 protein coding gene Chr7:63933443-64119567 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032822
 protein coding gene Chr7:58960668-59137884 (+)
PWK/PhJ MGP_PWKPhJ_G0031074
 protein coding gene Chr7:50763212-50940693 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030915
 protein coding gene Chr7:46929933-47104741 (+)
WSB/EiJ MGP_WSBEiJ_G0031472
 protein coding gene Chr7:59537984-59717536 (+)



Homology
more
  • Human Ortholog
    ATP10A, ATPase phospholipid transporting 10A (putative)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP10A, ATPase phospholipid transporting 10A (putative)
  • Synonyms
    ATP10C, ATPVA, ATPVC
  • Links
    NCBI Gene ID: 57194
    neXtProt AC: NX_O60312
    UniProt: O60312

  • Chr Location
    15q12; chr15:25672237-25865184 (-)  GRCh38
Human Diseases
less
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of this gene at the distal end of the p23DFiOD deletion may be responsible for the obesity phenotypes associated with that deletion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    123
  • cDNA Data
    47
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025324 Ensembl Gene Model | MGI Sequence Detail 173255 C57BL/6J ±  kb
    transcript ENSMUST00000168747 Ensembl | MGI Sequence Detail 5419 Not Applicable  
    polypeptide ENSMUSP00000129811 Ensembl | MGI Sequence Detail 1508 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 47
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 8
      Diseases 5
      Gene Ontology 9
      Phenotypes 48
    • Earliest
      J:29903 Russell LB, et al., Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse. Genetics. 1995 Dec;141(4):1547-62
    • Latest
      J:345883 Norris AC, et al., ATP10A deficiency results in male-specific infertility in mice. Front Cell Dev Biol. 2024;12:1310593
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory