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Osmr Gene Detail
Summary
  • Symbol
    Osmr
  • Name
    oncostatin M receptor
  • Synonyms
    OSMRB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330819
    NCBI Gene: 18414
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:6843049-6904434 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1825 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330819
 protein coding gene Chr15:6843049-6904450 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021699
 protein coding gene Chr15:3809800-3872696 (-)
A/J MGP_AJ_G0021660
 protein coding gene Chr15:3730720-3793245 (-)
AKR/J MGP_AKRJ_G0021638
 protein coding gene Chr15:3750581-3814271 (-)
BALB/cJ MGP_BALBcJ_G0021667
 protein coding gene Chr15:3642493-3703860 (-)
C3H/HeJ MGP_C3HHeJ_G0021443
 protein coding gene Chr15:3770112-3837595 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022106
 protein coding gene Chr15:3970473-4035753 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019643
 protein coding gene Chr15:3358950-3413964 (-)
CAST/EiJ MGP_CASTEiJ_G0020959
 protein coding gene Chr15:3748337-3811164 (-)
CBA/J MGP_CBAJ_G0021412
 protein coding gene Chr15:4033766-4096723 (-)
DBA/2J MGP_DBA2J_G0021536
 protein coding gene Chr15:3654890-3721346 (-)
FVB/NJ MGP_FVBNJ_G0021514
 protein coding gene Chr15:3584027-3647792 (-)
LP/J MGP_LPJ_G0021604
 protein coding gene Chr15:3716467-3798646 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021539
 protein coding gene Chr15:4239933-4310639 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022129
 protein coding gene Chr15:3774099-3836840 (-)
PWK/PhJ MGP_PWKPhJ_G0020702
 protein coding gene Chr15:3664621-3726968 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020540
 protein coding gene Chr15:3668846-3731876 (-)
WSB/EiJ MGP_WSBEiJ_G0021015
 protein coding gene Chr15:3702596-3766481 (-)



Homology
more
  • Human Ortholog
    OSMR, oncostatin M receptor
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSMR, oncostatin M receptor
  • Synonyms
    IL-31RB, IL-31R-beta, OSMRB, OSMRbeta, PLCA1
  • Links
    NCBI Gene ID: 9180
    neXtProt AC: NX_Q99650
    UniProt: Q99650

  • Chr Location
    5p13.1; chr5:38845858-38945596 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OSMR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit anemia, decreased hematocrit, and reduced erythroid progenitor, erythrocyte, platelet, and megakaryocyte cells. Homozygotes also show increased susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    47
  • cDNA Data
    50
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18414 NCBI Gene Model | MGI Sequence Detail 61386 C57BL/6J ±  kb
    transcript NM_011019 RefSeq | MGI Sequence Detail 4789 ZRU/MplStud  
    polypeptide O70458 UniProt | EBI | MGI Sequence Detail 971 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012060 oncostatin-M-specific receptor subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR040817 Leukemia inhibitory factor receptor, D2 domain
      IPR048497 Leukemia inhibitory factor receptor-like, Ig-like domain
      IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
      IPR050379 Type I Cytokine Receptor
    • GlyGen
      O70458 15 sites, 7 N-linked glycans (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 52
      Primer pair 4

      Microarray probesets 5
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 46
    • Earliest
      J:47670 Lindberg RA, et al., Cloning and characterization of a specific receptor for mouse oncostatin M. Mol Cell Biol. 1998 Jun;18(6):3357-67
    • Latest
      J:355493 Komori T, et al., Blockade of OSMRbeta signaling ameliorates skin lesions in a mouse model of human atopic dermatitis. FASEB J. 2024 Jan;38(1):e23359
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory