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Zfp148 Gene Detail
Summary
  • Symbol
    Zfp148
  • Name
    zinc finger protein 148
  • Synonyms
    2210405J08Rik, BERF-1, beta enolase repressor factor 1, BFCOL1, ZBP-89
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332234
    NCBI Gene: 22661
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:33201145-33324273 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 23.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2638 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332234
 protein coding gene Chr16:33201145-33324733 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022755
 protein coding gene Chr16:31575791-31715429 (+)
A/J MGP_AJ_G0022720
 protein coding gene Chr16:30068418-30192172 (+)
AKR/J MGP_AKRJ_G0022693
 protein coding gene Chr16:31127108-31259586 (+)
BALB/cJ MGP_BALBcJ_G0022722
 protein coding gene Chr16:30177025-30302093 (+)
C3H/HeJ MGP_C3HHeJ_G0022487
 protein coding gene Chr16:31254697-31382948 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023171
 protein coding gene Chr16:32275601-32410151 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020689
 protein coding gene Chr16:30433987-30521181 (+)
CAST/EiJ MGP_CASTEiJ_G0022015
 protein coding gene Chr16:31405748-31548583 (+)
CBA/J MGP_CBAJ_G0022457
 protein coding gene Chr16:33562603-33712455 (+)
DBA/2J MGP_DBA2J_G0022590
 protein coding gene Chr16:29880169-30009164 (+)
FVB/NJ MGP_FVBNJ_G0022565
 protein coding gene Chr16:29876442-30002237 (+)
LP/J MGP_LPJ_G0022657
 protein coding gene Chr16:31336022-31438051 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022584
 protein coding gene Chr16:32963247-33098972 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023183
 protein coding gene Chr16:31125106-31261604 (+)
PWK/PhJ MGP_PWKPhJ_G0021756
 protein coding gene Chr16:30262233-30389515 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021585
 protein coding gene Chr16:30923742-31047919 (+)
WSB/EiJ MGP_WSBEiJ_G0022059
 protein coding gene Chr16:31092567-31217294 (+)



Homology
more
  • Human Ortholog
    ZNF148, zinc finger protein 148
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF148, zinc finger protein 148
  • Synonyms
    BERF-1, BFCOL1, GDACCF, HT-BETA, pHZ-52, ZBP-89, ZFP148
  • Links
    NCBI Gene ID: 7707
    neXtProt AC: NX_Q9UQR1
    UniProt: Q9UQR1

  • Chr Location
    3q21.2; chr3:125225669-125375354 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of one allele results in haploinsufficient male infertility in which chimeric males display a loss of germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    64
  • cDNA Data
    169
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22661 NCBI Gene Model | MGI Sequence Detail 123129 C57BL/6J ±  kb
    transcript NM_001358570 RefSeq | MGI Sequence Detail 9759 ZRU/MplStud  
    polypeptide Q61624 UniProt | EBI | MGI Sequence Detail 794 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 169
      Primer pair 7

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1925897, MGI:2146444, MGI:2146606
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:38556 Hasegawa T, et al., Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. J Biol Chem. 1997 Feb 21;272(8):4915-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory