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Dok2 Gene Detail
Summary
  • Symbol
    Dok2
  • Name
    docking protein 2
  • Synonyms
    DokR, Frip, Frip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332623
    NCBI Gene: 13449
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:71003476-71015935 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.71 cM, cytoband D2-D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332623
 protein coding gene Chr14:71003336-71015935 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021550
 protein coding gene Chr14:65430174-65442631 (+)
A/J MGP_AJ_G0021509
 protein coding gene Chr14:64027175-64039630 (+)
AKR/J MGP_AKRJ_G0021485
 protein coding gene Chr14:65951874-65964314 (+)
BALB/cJ MGP_BALBcJ_G0021515
 protein coding gene Chr14:63792650-63805264 (+)
C3H/HeJ MGP_C3HHeJ_G0021292
 protein coding gene Chr14:65667321-65679676 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021954
 protein coding gene Chr14:68338402-68350742 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019494
 protein coding gene Chr14:61864734-61877025 (+)
CAST/EiJ MGP_CASTEiJ_G0020809
 protein coding gene Chr14:62261755-62274090 (+)
CBA/J MGP_CBAJ_G0021259
 protein coding gene Chr14:70495648-70508059 (+)
DBA/2J MGP_DBA2J_G0021382
 protein coding gene Chr14:63417025-63429735 (+)
FVB/NJ MGP_FVBNJ_G0021361
 protein coding gene Chr14:62845763-62858142 (+)
LP/J MGP_LPJ_G0021453
 protein coding gene Chr14:66668835-66681327 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021390
 protein coding gene Chr14:69379176-69391652 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021978
 protein coding gene Chr14:65212810-65226359 (+)
PWK/PhJ MGP_PWKPhJ_G0020553
 protein coding gene Chr14:60185130-60197405 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020386
 protein coding gene Chr14:61138763-61151315 (+)
WSB/EiJ MGP_WSBEiJ_G0020862
 protein coding gene Chr14:65525202-65538027 (+)



Homology
more
  • Human Ortholog
    DOK2, docking protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOK2, docking protein 2
  • Synonyms
    p56DOK, p56dok-2
  • Links
    NCBI Gene ID: 9046
    neXtProt AC: NX_O60496
    UniProt: O60496

  • Chr Location
    8p21.3; chr8:21908873-21913690 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    26 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal granulocyte physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    16
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022102 Ensembl Gene Model | MGI Sequence Detail 12460 C57BL/6J ±  kb
    transcript ENSMUST00000022698 Ensembl | MGI Sequence Detail 1795 Not Applicable  
    polypeptide ENSMUSP00000022698 Ensembl | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1261852
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:43960 Nelms K, et al., FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity. 1998 Jul;9(1):13-24
    • Latest
      J:270610 Chen M, et al., Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. J Clin Invest. 2019 Jan 2;129(1):215-222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory