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Inppl1 Gene Detail
Summary
  • Symbol
    Inppl1
  • Name
    inositol polyphosphate phosphatase-like 1
  • Synonyms
    SHIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333787
    NCBI Gene: 16332
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101471839-101487419 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.67 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333787
 protein coding gene Chr7:101471839-101487436 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032588
 protein coding gene Chr7:104834111-104849577 (-)
A/J MGP_AJ_G0032564
 protein coding gene Chr7:102166014-102181482 (-)
AKR/J MGP_AKRJ_G0032500
 protein coding gene Chr7:104611849-104627121 (-)
BALB/cJ MGP_BALBcJ_G0032575
 protein coding gene Chr7:101865501-101880733 (-)
C3H/HeJ MGP_C3HHeJ_G0032289
 protein coding gene Chr7:104982669-104999840 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033072
 protein coding gene Chr7:108780679-108795853 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030066
 protein coding gene Chr7:104520644-104536055 (-)
CAST/EiJ MGP_CASTEiJ_G0031615
 protein coding gene Chr7:96533834-96550025 (-)
CBA/J MGP_CBAJ_G0032255
 protein coding gene Chr7:112547949-112563101 (-)
DBA/2J MGP_DBA2J_G0032407
 protein coding gene Chr7:100493995-100509430 (-)
FVB/NJ MGP_FVBNJ_G0032363
 protein coding gene Chr7:100274888-100290010 (-)
LP/J MGP_LPJ_G0032496
 protein coding gene Chr7:106151092-106166560 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032397
 protein coding gene Chr7:113884238-113899936 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033094
 protein coding gene Chr7:103872548-103888173 (-)
PWK/PhJ MGP_PWKPhJ_G0031333
 protein coding gene Chr7:93603642-93619405 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031177
 protein coding gene Chr7:91163329-91179017 (-)
WSB/EiJ MGP_WSBEiJ_G0031732
 protein coding gene Chr7:104563573-104579102 (-)



Homology
more
  • Human Ortholog
    INPPL1, inositol polyphosphate phosphatase like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INPPL1, inositol polyphosphate phosphatase like 1
  • Synonyms
    OPSMD, SHIP2
  • Links
    NCBI Gene ID: 3636
    neXtProt AC: NX_O15357
    UniProt: O15357

  • Chr Location
    11q13.4; chr11:72223563-72239147 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human INPPL1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice display decreased postnatal growth, decreased circulating levels of leptin, free fatty acids, triglycerides, and total cholesterol, and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    126
  • cDNA Data
    82
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16332 NCBI Gene Model | MGI Sequence Detail 15581 C57BL/6J ±  kb
    transcript NM_001412588 RefSeq | MGI Sequence Detail 5316 C57BL/6  
    polypeptide Q6P549 UniProt | EBI | MGI Sequence Detail 1257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 82
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 8
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:336310 Fernandes S, et al., Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment. iScience. 2023 Feb 17;26(2):106071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory