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Srp72 Gene Detail
Summary
  • Symbol
    Srp72
  • Name
    signal recognition particle 72
  • Synonyms
    5730576P14Rik, 72kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333795
    NCBI Gene: 66661
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77122548-77147782 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    706 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333795
 protein coding gene Chr5:77122530-77147784 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029651
 protein coding gene Chr5:77188367-77216704 (+)
A/J MGP_AJ_G0029619
 protein coding gene Chr5:74237961-74263185 (+)
AKR/J MGP_AKRJ_G0029567
 protein coding gene Chr5:76660891-76686864 (+)
BALB/cJ MGP_BALBcJ_G0029628
 protein coding gene Chr5:74972946-74999433 (+)
C3H/HeJ MGP_C3HHeJ_G0029351
 protein coding gene Chr5:77033237-77060437 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030082
 protein coding gene Chr5:80275994-80305836 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027323
 protein coding gene Chr5:69868102-69893347 (+)
CAST/EiJ MGP_CASTEiJ_G0028759
 protein coding gene Chr5:76238871-76268865 (+)
CBA/J MGP_CBAJ_G0029320
 protein coding gene Chr5:82915771-82950664 (+)
DBA/2J MGP_DBA2J_G0029465
 protein coding gene Chr5:74298815-74324657 (+)
FVB/NJ MGP_FVBNJ_G0029426
 protein coding gene Chr5:73496540-73522239 (+)
LP/J MGP_LPJ_G0029552
 protein coding gene Chr5:77625624-77652835 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029454
 protein coding gene Chr5:86056056-86081363 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030115
 protein coding gene Chr5:76210879-76237510 (+)
PWK/PhJ MGP_PWKPhJ_G0028482
 protein coding gene Chr5:73314817-73340430 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028317
 protein coding gene Chr5:75565810-75594359 (+)
WSB/EiJ MGP_WSBEiJ_G0028839
 protein coding gene Chr5:76539233-76569412 (+)



Homology
more
  • Human Ortholog
    SRP72, signal recognition particle 72
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRP72, signal recognition particle 72
  • Synonyms
    BMFF, BMFS1, HEL103
  • Links
    NCBI Gene ID: 6731
    neXtProt AC: NX_O76094
    UniProt: O76094

  • Chr Location
    4q12; chr4:56467617-56503681 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66661 NCBI Gene Model | MGI Sequence Detail 25235 C57BL/6J ±  kb
transcript NM_025691 RefSeq | MGI Sequence Detail 3605 C57BL/6  
polypeptide NP_079967 RefSeq | MGI Sequence Detail 671 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR026270 Signal recognition particle, SRP72 subunit
    IPR013699 Signal recognition particle, SRP72 subunit, RNA-binding
    IPR031545 Signal recognition particle subunit SRP72, TPR-like repeat
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
  • GlyGen
    F8VQC1 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913911, MGI:2140810, MGI:2141290, MGI:3039569
References
more
  • Summaries
    All 40
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory