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Ccr6 Gene Detail
Summary
  • Symbol
    Ccr6
  • Name
    C-C motif chemokine receptor 6
  • Synonyms
    Cmkbr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333797
    NCBI Gene: 12458
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:8454875-8475973 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.90 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    626 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333797
 protein coding gene Chr17:8454875-8477353 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023130
 protein coding gene Chr17:5701054-5724007 (+)
A/J MGP_AJ_G0023098
 protein coding gene Chr17:5732897-5757403 (+)
AKR/J MGP_AKRJ_G0023063
 protein coding gene Chr17:5397540-5418502 (+)
BALB/cJ MGP_BALBcJ_G0023098
 protein coding gene Chr17:5535608-5558821 (+)
C3H/HeJ MGP_C3HHeJ_G0022861
 protein coding gene Chr17:5672172-5695415 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023542
 protein coding gene Chr17:5973050-5997424 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021066
 protein coding gene Chr17:8602120-8625343 (-)
CAST/EiJ MGP_CASTEiJ_G0022376
 protein coding gene Chr17:5654704-5682797 (+)
CBA/J MGP_CBAJ_G0022833
 protein coding gene Chr17:6175774-6203133 (+)
DBA/2J MGP_DBA2J_G0022966
 protein coding gene Chr17:5402361-5425610 (+)
FVB/NJ MGP_FVBNJ_G0022935
 protein coding gene Chr17:5322683-5345949 (+)
LP/J MGP_LPJ_G0023037
 protein coding gene Chr17:5524560-5547834 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022956
 protein coding gene Chr17:5919233-5942971 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023567
 protein coding gene Chr17:5679310-5700204 (+)
PWK/PhJ MGP_PWKPhJ_G0022124
 protein coding gene Chr17:5024771-5049343 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021953
 protein coding gene Chr17:4940498-4963736 (+)
WSB/EiJ MGP_WSBEiJ_G0022432
 protein coding gene Chr17:5978116-6004582 (+)



Homology
more
  • Human Ortholog
    CCR6, C-C motif chemokine receptor 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCR6, C-C motif chemokine receptor 6
  • Synonyms
    BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
  • Links
    NCBI Gene ID: 1235
    neXtProt AC: NX_P51684
    UniProt: P51684

  • Chr Location
    6q27; chr6:167111795-167139141 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 6 alleles in 9 genetic backgrounds
    1 images
    469 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have decreased inflammatory responses, aberrant trafficking of lymphocytes and dendritic cells, and decreased expression of many inflammatory mediators.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    82
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040899 Ensembl Gene Model | MGI Sequence Detail 21099 C57BL/6J ±  kb
    transcript ENSMUST00000164411 Ensembl | MGI Sequence Detail 1398 Not Applicable  
    polypeptide ENSMUSP00000131153 Ensembl | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 528
      Developmental Gene Expression 4
      Diseases 6
      Gene Ontology 14
      Phenotypes 469
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory