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Mbd3 Gene Detail
Summary
  • Symbol
    Mbd3
  • Name
    methyl-CpG binding domain protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333812
    NCBI Gene: 17192
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80228373-80235365 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333812
 protein coding gene Chr10:80228373-80235384 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017501
 protein coding gene Chr10:80995244-81002256 (-)
A/J MGP_AJ_G0017479
 protein coding gene Chr10:78160547-78167548 (-)
AKR/J MGP_AKRJ_G0017440
 protein coding gene Chr10:80303581-80310600 (-)
BALB/cJ MGP_BALBcJ_G0017441
 protein coding gene Chr10:78392012-78399018 (-)
C3H/HeJ MGP_C3HHeJ_G0017264
 protein coding gene Chr10:80392609-80399603 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017895
 protein coding gene Chr10:83798025-83805034 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015583
 protein coding gene Chr10:74380160-74387466 (-)
CAST/EiJ MGP_CASTEiJ_G0016831
 protein coding gene Chr10:80607991-80615193 (-)
CBA/J MGP_CBAJ_G0017236
 protein coding gene Chr10:87045178-87052189 (-)
DBA/2J MGP_DBA2J_G0017342
 protein coding gene Chr10:77378543-77385899 (-)
FVB/NJ MGP_FVBNJ_G0017336
 protein coding gene Chr10:76577721-76584733 (-)
LP/J MGP_LPJ_G0017413
 protein coding gene Chr10:81471596-81480081 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017362
 protein coding gene Chr10:88990820-88997833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017936
 protein coding gene Chr10:80288884-80295885 (-)
PWK/PhJ MGP_PWKPhJ_G0016612
 protein coding gene Chr10:77256623-77263649 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016401
 protein coding gene Chr10:79259647-79266635 (-)
WSB/EiJ MGP_WSBEiJ_G0016891
 protein coding gene Chr10:80326210-80333209 (-)



Homology
more
  • Human Ortholog
    MBD3, methyl-CpG binding domain protein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBD3, methyl-CpG binding domain protein 3
  • Links
    NCBI Gene ID: 53615
    neXtProt AC: NX_O95983
    UniProt: O95983

  • Chr Location
    19p13.3; chr19:1573596-1592865 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience deficiencies as embryos around implantation and die before birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    47
  • cDNA Data
    117
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17192 NCBI Gene Model | MGI Sequence Detail 6993 C57BL/6J ±  kb
    transcript NM_013595 RefSeq | MGI Sequence Detail 1659 ZRU/MplStud  
    polypeptide Q9Z2D8 UniProt | EBI | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010216 methyl-CpG-binding domain protein 3
      (term hierarchy)
    • InterPro Domains
      IPR016177 DNA-binding domain superfamily
      IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region
      IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain
      IPR001739 Methyl-CpG DNA binding
    • GlyGen
      Q9Z2D8 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 117
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143531, MGI:2143734
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 13
      Gene Ontology 17
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:278486 Burgold T, et al., The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment. EMBO J. 2019 Jun 17;38(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory