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Slc31a1 Gene Detail
Summary
  • Symbol
    Slc31a1
  • Name
    solute carrier family 31, member 1
  • Synonyms
    4930445G01Rik, Ctr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333843
    NCBI Gene: 20529
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:62278964-62310006 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.11 cM, cytoband C1-C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    660 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333843
 protein coding gene Chr4:62278821-62310006 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028349
 protein coding gene Chr4:61340673-61374912 (+)
A/J MGP_AJ_G0028310
 protein coding gene Chr4:59118969-59150207 (+)
AKR/J MGP_AKRJ_G0028259
 protein coding gene Chr4:60758934-60789936 (+)
BALB/cJ MGP_BALBcJ_G0028330
 protein coding gene Chr4:59295589-59328081 (+)
C3H/HeJ MGP_C3HHeJ_G0028048
 protein coding gene Chr4:61265578-61299943 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028770
 protein coding gene Chr4:63444875-63479181 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026076
 protein coding gene Chr4:56410341-56441936 (+)
CAST/EiJ MGP_CASTEiJ_G0027484
 protein coding gene Chr4:59198742-59233886 (+)
CBA/J MGP_CBAJ_G0028015
 protein coding gene Chr4:65641909-65677251 (+)
DBA/2J MGP_DBA2J_G0028165
 protein coding gene Chr4:58977157-59008700 (+)
FVB/NJ MGP_FVBNJ_G0028130
 protein coding gene Chr4:58223843-58254916 (+)
LP/J MGP_LPJ_G0028262
 protein coding gene Chr4:61625860-61656974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028157
 protein coding gene Chr4:68779356-68813122 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028806
 protein coding gene Chr4:60856467-60890508 (+)
PWK/PhJ MGP_PWKPhJ_G0027211
 protein coding gene Chr4:57452512-57486435 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027040
 protein coding gene Chr4:58300827-58335003 (+)
WSB/EiJ MGP_WSBEiJ_G0027564
 protein coding gene Chr4:60840345-60873715 (+)



Homology
more
  • Human Ortholog
    SLC31A1, solute carrier family 31 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC31A1, solute carrier family 31 member 1
  • Synonyms
    COPT1, CTR1, NSCT
  • Links
    NCBI Gene ID: 1317
    neXtProt AC: NX_O15431
    UniProt: O15431

  • Chr Location
    9q32; chr9:113221544-113264492 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis. Mice heterozygous for a null allele exhibit decreased copper levels in the blood and several organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    137
  • cDNA Data
    19
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066150 Ensembl Gene Model | MGI Sequence Detail 31043 C57BL/6J ±  kb
    transcript ENSMUST00000084526 Ensembl | MGI Sequence Detail 3718 Not Applicable  
    polypeptide ENSMUSP00000081574 Ensembl | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 19
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925416, MGI:2140357, MGI:2140433
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 27
    • Earliest
      J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
    • Latest
      J:346176 Haberkiewicz O, et al., Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease. Int J Mol Sci. 2022 Sep 28;23(19)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory