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Klf9 Gene Detail
Summary
  • Symbol
    Klf9
  • Name
    Kruppel-like transcription factor 9
  • Synonyms
    2310051E17Rik, Bteb1, BTEB-1, Klf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333856
    NCBI Gene: 16601
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:23118590-23145493 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 17.90 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    731 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333856
 protein coding gene Chr19:23118590-23145498 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024983
 protein coding gene Chr19:21269406-21299439 (+)
A/J MGP_AJ_G0024960
 protein coding gene Chr19:20106309-20131817 (+)
AKR/J MGP_AKRJ_G0024930
 protein coding gene Chr19:20879568-20905372 (+)
BALB/cJ MGP_BALBcJ_G0024959
 protein coding gene Chr19:20148590-20174541 (+)
C3H/HeJ MGP_C3HHeJ_G0024717
 protein coding gene Chr19:20841101-20866305 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025401
 protein coding gene Chr19:21959912-21988627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022820
 protein coding gene Chr19:20292188-20319033 (+)
CAST/EiJ MGP_CASTEiJ_G0024185
 protein coding gene Chr19:20548420-20575549 (+)
CBA/J MGP_CBAJ_G0024695
 protein coding gene Chr19:22889864-22918835 (+)
DBA/2J MGP_DBA2J_G0024827
 protein coding gene Chr19:20124173-20149746 (+)
FVB/NJ MGP_FVBNJ_G0024788
 protein coding gene Chr19:19973805-20001094 (+)
LP/J MGP_LPJ_G0024911
 protein coding gene Chr19:21221463-21248119 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024815
 protein coding gene Chr19:22976121-23017452 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025456
 protein coding gene Chr19:20862861-20890005 (+)
PWK/PhJ MGP_PWKPhJ_G0023934
 protein coding gene Chr19:19693886-19719540 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023739
 protein coding gene Chr19:20085525-20109613 (+)
WSB/EiJ MGP_WSBEiJ_G0024253
 protein coding gene Chr19:20887574-20915739 (+)



Homology
more
  • Human Ortholog
    KLF9, KLF transcription factor 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF9, KLF transcription factor 9
  • Synonyms
    BTEB, BTEB1
  • Links
    NCBI Gene ID: 687
    neXtProt AC: NX_Q13886
    UniProt: Q13886

  • Chr Location
    9q21.12; chr9:70384604-70414657 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display only mild neurological defects evident by impaired performance in rotarod and contextual fear-conditioning tests.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1085
  • Tissues
    156
  • cDNA Data
    17
  • Literature Summary
    20
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16601 NCBI Gene Model | MGI Sequence Detail 26904 C57BL/6J ±  kb
transcript NM_010638 RefSeq | MGI Sequence Detail 4481 C57BL/6  
polypeptide O35739 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 18
    Primer pair 5

    Microarray probesets 10
Other
Accession IDs
less
MGI:1917523, MGI:2147456
References
more
  • Summaries
    All 102
    Developmental Gene Expression 20
    Gene Ontology 8
    Phenotypes 47
  • Earliest
    J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
  • Latest
    J:353412 Zhang Y, et al., Glucocorticoids increase adiposity by stimulating Kruppel-like factor 9 expression in macrophages. Nat Commun. 2024 Feb 8;15(1):1190
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory