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Arhgap31 Gene Detail
Summary
  • Symbol
    Arhgap31
  • Name
    Rho GTPase activating protein 31
  • Synonyms
    CdGAP, mKIAA1204
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333857
    NCBI Gene: 12549
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38418705-38533397 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.87 cM, cytoband B4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2677 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333857
 protein coding gene Chr16:38418702-38533636 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022820
 protein coding gene Chr16:37134039-37260738 (-)
A/J MGP_AJ_G0022785
 protein coding gene Chr16:35302861-35415665 (-)
AKR/J MGP_AKRJ_G0022757
 protein coding gene Chr16:36634197-36758681 (-)
BALB/cJ MGP_BALBcJ_G0022786
 protein coding gene Chr16:35414945-35530185 (-)
C3H/HeJ MGP_C3HHeJ_G0022550
 protein coding gene Chr16:36741381-36859702 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023233
 protein coding gene Chr16:37980221-38108228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020748
 protein coding gene Chr16:35674844-35789288 (-)
CAST/EiJ MGP_CASTEiJ_G0022076
 protein coding gene Chr16:36894565-37016637 (-)
CBA/J MGP_CBAJ_G0022521
 protein coding gene Chr16:39649947-39776461 (-)
DBA/2J MGP_DBA2J_G0022653
 protein coding gene Chr16:35179864-35292998 (-)
FVB/NJ MGP_FVBNJ_G0022628
 protein coding gene Chr16:35206602-35321161 (-)
LP/J MGP_LPJ_G0022721
 protein coding gene Chr16:36814052-36935324 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022647
 protein coding gene Chr16:38753110-38875422 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023248
 protein coding gene Chr16:36602713-36722233 (-)
PWK/PhJ MGP_PWKPhJ_G0021816
 protein coding gene Chr16:35595006-35710189 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021647
 protein coding gene Chr16:36496854-36616677 (-)
WSB/EiJ MGP_WSBEiJ_G0022120
 protein coding gene Chr16:36666124-36788190 (-)



Homology
more
  • Human Ortholog
    ARHGAP31, Rho GTPase activating protein 31
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP31, Rho GTPase activating protein 31
  • Synonyms
    AOS, AOS1, CDGAP
  • Links
    NCBI Gene ID: 57514
    neXtProt AC: NX_Q2M1Z3
    UniProt: Q2M1Z3

  • Chr Location
    3q13.32-q13.33; chr3:119294383-119420714 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ARHGAP31 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial lethality during fetal growth through weaning and abnormal vascular development associated with subcutaneous edema and hemorrhages, pale meninges and liver, and reduced VEGF-mediated capillary sprouting from aortic ring explants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    20
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12549 NCBI Gene Model | MGI Sequence Detail 114693 C57BL/6J ±  kb
    transcript NM_020260 RefSeq | MGI Sequence Detail 7722 Not Specified  
    polypeptide A6X8Z5 UniProt | EBI | MGI Sequence Detail 1425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005228 Rho GTPase-activating protein 31
      (term hierarchy)
    • InterPro Domains
      IPR051576 PX Domain-Containing Rho GAP
      IPR000198 Rho GTPase-activating protein domain
      IPR008936 Rho GTPase activation protein
    • GlyGen
      A6X8Z5 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 17
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1923377, MGI:2146575
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:50532 Lamarche-Vane N, et al., CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J Biol Chem. 1998 Oct 30;273(44):29172-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory