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Cd5l Gene Detail
Summary
  • Symbol
    Cd5l
  • Name
    CD5 antigen-like
  • Synonyms
    AAC-11, AIM, AIM/Spalpha, Api6, Pdp 1/6, Sp-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1334419
    NCBI Gene: 11801
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87265188-87278380 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1334419
 protein coding gene Chr3:87265188-87278381 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027361
 protein coding gene Chr3:87444228-87457215 (+)
A/J MGP_AJ_G0027325
 protein coding gene Chr3:84478261-84491246 (+)
AKR/J MGP_AKRJ_G0027291
 protein coding gene Chr3:86530622-86543609 (+)
BALB/cJ MGP_BALBcJ_G0027334
 protein coding gene Chr3:84573321-84586318 (+)
C3H/HeJ MGP_C3HHeJ_G0027077
 protein coding gene Chr3:86804345-86817344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027780
 protein coding gene Chr3:90684669-90697860 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025133
 protein coding gene Chr3:80125196-80137644 (+)
CAST/EiJ MGP_CASTEiJ_G0026524
 protein coding gene Chr3:87037536-87051000 (+)
CBA/J MGP_CBAJ_G0027052
 protein coding gene Chr3:93745250-93761135 (+)
DBA/2J MGP_DBA2J_G0027188
 protein coding gene Chr3:83985978-83998918 (+)
FVB/NJ MGP_FVBNJ_G0027157
 protein coding gene Chr3:82291108-82304080 (+)
LP/J MGP_LPJ_G0027296
 protein coding gene Chr3:88402981-88415952 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027176
 protein coding gene Chr3:100037031-100052718 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027838
 protein coding gene Chr3:86306774-86319787 (+)
PWK/PhJ MGP_PWKPhJ_G0026257
 protein coding gene Chr3:83779416-83792894 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026074
 protein coding gene Chr3:85496197-85509836 (+)
WSB/EiJ MGP_WSBEiJ_G0026603
 protein coding gene Chr3:86678818-86692995 (+)



Homology
more
  • Human Ortholog
    CD5L, CD5 molecule like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD5L, CD5 molecule like
  • Synonyms
    AIM, API6, CT-2, hAIM, PRO229, Spalpha, SP-ALPHA
  • Links
    NCBI Gene ID: 922
    neXtProt AC: NX_O43866
    UniProt: O43866

  • Chr Location
    1q23.1; chr1:157827068-157898256 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit enhanced and prolonged bacterial-induced granuloma formation and increased apoptosis of NKT and T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    35
  • cDNA Data
    31
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015854 Ensembl Gene Model | MGI Sequence Detail 13193 C57BL/6J ±  kb
    transcript ENSMUST00000015998 Ensembl | MGI Sequence Detail 2036 Not Applicable  
    polypeptide ENSMUSP00000015998 Ensembl | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 31
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1333862, MGI:2139622
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 4
      Phenotypes 33
    • Earliest
      J:48250 Iwama A, et al., Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15;26(12):3034-43
    • Latest
      J:348392 Oliveira L, et al., CD5L as a promising biological therapeutic for treating sepsis. Nat Commun. 2024 May 15;15(1):4119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory