About   Help   FAQ
Elf5 Gene Detail
Summary
  • Symbol
    Elf5
  • Name
    E74-like factor 5
  • Synonyms
    ESE-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335079
    NCBI Gene: 13711
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103242443-103281334 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.43 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1096 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335079
 protein coding gene Chr2:103242033-103281334 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026203
 protein coding gene Chr2:105393412-105433874 (+)
A/J MGP_AJ_G0026164
 protein coding gene Chr2:101041557-101081699 (+)
AKR/J MGP_AKRJ_G0026145
 protein coding gene Chr2:103780147-103823845 (+)
BALB/cJ MGP_BALBcJ_G0026173
 protein coding gene Chr2:101328254-101368828 (+)
C3H/HeJ MGP_C3HHeJ_G0025924
 protein coding gene Chr2:104134593-104173193 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026624
 protein coding gene Chr2:108931287-108973874 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024015
 protein coding gene Chr2:96720686-96761816 (+)
CAST/EiJ MGP_CASTEiJ_G0025389
 protein coding gene Chr2:104602523-104646441 (+)
CBA/J MGP_CBAJ_G0025902
 protein coding gene Chr2:112657042-112699409 (+)
DBA/2J MGP_DBA2J_G0026038
 protein coding gene Chr2:100608282-100647412 (+)
FVB/NJ MGP_FVBNJ_G0026001
 protein coding gene Chr2:99607904-99648423 (+)
LP/J MGP_LPJ_G0026142
 protein coding gene Chr2:105528546-105568851 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026027
 protein coding gene Chr2:116574979-116622973 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026678
 protein coding gene Chr2:104001441-104040368 (+)
PWK/PhJ MGP_PWKPhJ_G0025124
 protein coding gene Chr2:100113030-100158293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024925
 protein coding gene Chr2:103219935-103260886 (+)
WSB/EiJ MGP_WSBEiJ_G0025456
 protein coding gene Chr2:104705148-104746550 (+)



Homology
more
  • Human Ortholog
    ELF5, E74 like ETS transcription factor 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELF5, E74 like ETS transcription factor 5
  • Synonyms
    ESE2
  • Links
    NCBI Gene ID: 2001
    neXtProt AC: NX_Q9UKW6
    UniProt: Q9UKW6

  • Chr Location
    11p13; chr11:34478791-34525193 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 7 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality. Embryos homozygous for one null allele failed to develop extraembryonic ectoderm, did not maintain trophoblast stem cells, and had abnormal or absent mesoderm. Mice heterozygous for another allele had impaired lactation and mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    148
  • cDNA Data
    84
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13711 NCBI Gene Model | MGI Sequence Detail 38892 C57BL/6J ±  kb
    transcript NM_010125 RefSeq | MGI Sequence Detail 2216 C57BL/6  
    polypeptide Q8VDK3 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 85
      Primer pair 12
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 42
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:346388 Kim U, et al., DeltaNp63 regulates MDSC survival and metabolism in triple-negative breast cancer. iScience. 2024 Apr 19;27(4):109366
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory