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Cyth3 Gene Detail
Summary
  • Symbol
    Cyth3
  • Name
    cytohesin 3
  • Synonyms
    cytohesin 3, Grp1, Pscd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335107
    NCBI Gene: 19159
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:143608202-143696005 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 82.36 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2199 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335107
 protein coding gene Chr5:143608202-143696005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030335
 protein coding gene Chr5:148979496-149070965 (+)
A/J MGP_AJ_G0030304
 protein coding gene Chr5:142572621-142661210 (+)
AKR/J MGP_AKRJ_G0030236
 protein coding gene Chr5:147037511-147123704 (+)
BALB/cJ MGP_BALBcJ_G0030321
 protein coding gene Chr5:143823094-143910385 (+)
C3H/HeJ MGP_C3HHeJ_G0030032
 protein coding gene Chr5:147861696-147950899 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030766
 protein coding gene Chr5:154414022-154504648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027984
 protein coding gene Chr5:136339906-136430491 (+)
CAST/EiJ MGP_CASTEiJ_G0029437
 protein coding gene Chr5:147368399-147463678 (+)
CBA/J MGP_CBAJ_G0030002
 protein coding gene Chr5:160777806-160869789 (+)
DBA/2J MGP_DBA2J_G0030152
 protein coding gene Chr5:142338728-142433306 (+)
FVB/NJ MGP_FVBNJ_G0030107
 protein coding gene Chr5:141547736-141636769 (+)
LP/J MGP_LPJ_G0030238
 protein coding gene Chr5:149570231-149674840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030138
 protein coding gene Chr5:163157889-163248430 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030806
 protein coding gene Chr5:146898134-146990820 (+)
PWK/PhJ MGP_PWKPhJ_G0029152
 protein coding gene Chr5:141436404-141525999 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028988
 protein coding gene Chr5:144653121-144745229 (+)
WSB/EiJ MGP_WSBEiJ_G0029510
 protein coding gene Chr5:147691096-147788183 (+)



Homology
more
  • Human Ortholog
    CYTH3, cytohesin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYTH3, cytohesin 3
  • Synonyms
    ARNO3, cytohesin-3, GRP1, PSCD3
  • Links
    NCBI Gene ID: 9265
    neXtProt AC: NX_O43739
    UniProt: O43739

  • Chr Location
    7p22.1; chr7:6161779-6272644 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele do not develop overt diabetes but do show reduced insulin receptor signaling in liver and adipose tissue. Under aging conditions or a high-fat diet, homozygotes show decreased weight gain with a significant reduction of body fat due to increased lipid excretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    68
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19159 NCBI Gene Model | MGI Sequence Detail 87804 C57BL/6J ±  kb
    transcript NM_001163548 RefSeq | MGI Sequence Detail 4073 ZRU/MplStud  
    polypeptide O08967 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 69
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140949
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 8
    • Earliest
      J:39322 Klarlund JK, et al., Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains [see comments]. Science. 1997 Mar 28;275(5308):1927-30
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory