Prkag2 MGI Mouse Gene Detail - MGI:1336153 - protein kinase, AMP-activated, gamma 2 non-catalytic subunit

Symbol

Prkag2
Name

protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms

2410051C13Rik

Feature Type

protein coding gene
IDs

MGI:1336153
NCBI Gene: 108099
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr5:25067742-25305640 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 11.93 cM
Mapping Data

2 experiments

SNPs within 2kb

7700 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336153	protein coding gene	Chr5:25067733-25311576 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029357	protein coding gene	Chr5:22625468-22884896 (-)
A/J	MGP_AJ_G0029323	protein coding gene	Chr5:21835821-22086702 (-)
AKR/J	MGP_AKRJ_G0029274	protein coding gene	Chr5:22720509-22978435 (-)
BALB/cJ	MGP_BALBcJ_G0029334	protein coding gene	Chr5:22349505-22594048 (-)
C3H/HeJ	MGP_C3HHeJ_G0029054	protein coding gene	Chr5:22830519-23080960 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029787	protein coding gene	Chr5:24135034-24392574 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027025	protein coding gene	Chr5:19766567-20009692 (-)
CAST/EiJ	MGP_CASTEiJ_G0028466	protein coding gene	Chr5:22031689-22284080 (-)
CBA/J	MGP_CBAJ_G0029021	protein coding gene	Chr5:24550741-24824233 (-)
DBA/2J	MGP_DBA2J_G0029172	protein coding gene	Chr5:22124846-22365644 (-)
FVB/NJ	MGP_FVBNJ_G0029130	protein coding gene	Chr5:21502552-21742585 (-)
LP/J	MGP_LPJ_G0029256	protein coding gene	Chr5:23028484-23288803 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029159	protein coding gene	Chr5:25634734-25887895 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029821	protein coding gene	Chr5:22361962-22612230 (-)
PWK/PhJ	MGP_PWKPhJ_G0028190	protein coding gene	Chr5:21222575-21471293 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028021	protein coding gene	Chr5:21709358-21959928 (-)
WSB/EiJ	MGP_WSBEiJ_G0028546	protein coding gene	Chr5:22443155-22694594 (-)

Human Ortholog

PRKAG2, protein kinase AMP-activated non-catalytic subunit gamma 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKAG2, protein kinase AMP-activated non-catalytic subunit gamma 2
Synonyms

AAKG, AAKG2, CMH6, H91620p, WPWS
Links

HGNC:9386

NCBI Gene ID: 51422

neXtProt AC: NX_Q9UGJ0

UniProt: Q9UGJ0
Chr Location

7q36.1; chr7:151556124-151877214 (-) GRCh38

MGI Vertebrate Homology

Prkag2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRKAG2
Gene Tree

Prkag2

Diseases

4 with human PRKAG2 associations

				Human Disease	Mouse Models
				glycogen storage disease IDs glycogen storage disease DOID:2747 ICD10CM:E74.0 ICD9CM:271.0 MESH:D006008 NCI:C61272 UMLS_CUI:C0017919
				hypertrophic cardiomyopathy 6 IDs hypertrophic cardiomyopathy 6 DOID:0110312 OMIM:600858
				lethal congenital glycogen storage disease of heart IDs lethal congenital glycogen storage disease of heart DOID:0090101 ICD10CM:E74.0+ ICD10CM:G73.6* OMIM:261740 ORDO:439854
				Wolff-Parkinson-White syndrome IDs Wolff-Parkinson-White syndrome DOID:384 DOID:10392 ICD10CM:I45.6 ICD9CM:426.7 MESH:D014927 NCI:C35132 OMIM:194200 UMLS_CUI:C0043202 UMLS_CUI:C0392470

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

3
Radiation induced

2
Spontaneous

1
Targeted

7
Genomic Mutations

5 involving Prkag2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous constitutively active mutants develop age related obesity caused by polyphagia, glucose intolerance and insulin resistance and exhibit slowing of heart rate.

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All GO Annotations

47
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

888
Tissues

130
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PRKAG2

Xenbase prkag2

ZFIN prkag2a, prkag2b

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All Sequences

92
RefSeq

32
UniProt

8
CCDS

CCDS19130.1, CCDS51437.1, CCDS80231.1

Ensembl

ENSMUSG00000028944 (Evidence)
NCBI Gene

108099

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028944	Ensembl Gene Model \| MGI Sequence Detail	237899	C57BL/6J	± kb
transcript	ENSMUST00000030784	Ensembl \| MGI Sequence Detail	3331	Not Applicable
polypeptide	ENSMUSP00000030784	Ensembl \| MGI Sequence Detail	566	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000013226 5'-AMP-activated protein kinase subunit gamma-2

(term hierarchy)
InterPro Domains

IPR050511 AMP-activated protein kinase gamma/SDS23 families

IPR000644 CBS domain

IPR046342 CBS domain superfamily

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All nucleic 25

cDNA 14

Primer pair 10

Other 1

Microarray probesets 9

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MGI:1920950, MGI:2141005

Summaries

All 67

Developmental Gene Expression 4

Diseases 1

Gene Ontology 8

Phenotypes 28
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prkag2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50399	Chr5:25306050-25306062 (-)	-416 bp
Tssr50398	Chr5:25305888-25305930 (-)	-269 bp
Tssr50397	Chr5:25305622-25305655 (-)	1 bp
Tssr50396	Chr5:25305594-25305612 (-)	37 bp
Tssr50395	Chr5:25305577-25305584 (-)	59 bp
Tssr50394	Chr5:25305398-25305455 (-)	213 bp
Tssr50391	Chr5:25264615-25264625 (-)	41,020 bp
Tssr50390	Chr5:25264440-25264451 (-)	41,194 bp
Tssr50389	Chr5:25200882-25200917 (-)	104,740 bp
Tssr50388	Chr5:25200857-25200864 (-)	104,779 bp
Tssr50387	Chr5:25200798-25200809 (-)	104,836 bp
Tssr50386	Chr5:25200746-25200757 (-)	104,888 bp
Tssr50385	Chr5:25200691-25200705 (-)	104,942 bp
Tssr50384	Chr5:25200674-25200679 (-)	104,963 bp
Tssr50383	Chr5:25130404-25130418 (-)	175,229 bp
Tssr50382	Chr5:25130381-25130395 (-)	175,252 bp
Tssr50381	Chr5:25113761-25113775 (-)	191,872 bp
Tssr50380	Chr5:25113669-25113681 (-)	191,965 bp
Tssr50379	Chr5:25113558-25113581 (-)	192,070 bp
Tssr50378	Chr5:25113428-25113480 (-)	192,186 bp
Tssr50377	Chr5:25113372-25113426 (-)	192,241 bp
Tssr50376	Chr5:25107443-25107454 (-)	198,191 bp
Tssr50375	Chr5:25094912-25094925 (-)	210,721 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24