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Klrc1 Gene Detail
Summary
  • Symbol
    Klrc1
  • Name
    killer cell lectin-like receptor subfamily C, member 1
  • Synonyms
    CD159a, NKG2A, NKG2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336161
    NCBI Gene: 16641
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129642978-129655936 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM, cytoband G1-2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336161
 protein coding gene Chr6:129642978-129659815 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031357
 protein coding gene Chr6:133319960-133350324 (-)
A/J MGP_AJ_G0031328
 protein coding gene Chr6:128224348-128236399 (-)
AKR/J MGP_AKRJ_G0031256
 protein coding gene Chr6:131728421-131740347 (-)
BALB/cJ MGP_BALBcJ_G0031335
 protein coding gene Chr6:127877872-127890188 (-)
C3H/HeJ MGP_C3HHeJ_G0031059
 protein coding gene Chr6:131922101-131935000 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031794
 protein coding gene Chr6:136832842-136886139 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028939
 protein coding gene Chr6:126578400-126590105 (-)
CAST/EiJ MGP_CASTEiJ_G0030437
 protein coding gene Chr6:132183849-132196672 (-)
CBA/J MGP_CBAJ_G0031019
 protein coding gene Chr6:142217302-142229281 (-)
DBA/2J MGP_DBA2J_G0031176
 protein coding gene Chr6:127176093-127188975 (-)
FVB/NJ MGP_FVBNJ_G0031126
 protein coding gene Chr6:126065667-126082051 (-)
LP/J MGP_LPJ_G0031256
 protein coding gene Chr6:133545967-133561113 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031163
 protein coding gene Chr6:146097915-146115501 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031827
 protein coding gene Chr6:131803358-131815292 (-)
PWK/PhJ MGP_PWKPhJ_G0030155
 protein coding gene Chr6:125461902-125478138 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029984
 protein coding gene Chr6:129819358-129837694 (-)
WSB/EiJ MGP_WSBEiJ_G0030525
 protein coding gene Chr6:132225843-132262390 (-)



Homology
more
  • Human Ortholog
    KLRC1, killer cell lectin like receptor C1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRC1, killer cell lectin like receptor C1
  • Synonyms
    CD159A, NKG2, NKG2A
  • Links
    NCBI Gene ID: 3821
    neXtProt AC: NX_P26715
    UniProt: P26715

  • Chr Location
    12p13.2; chr12:10442264-10454685 (-)  GRCh38
  • Human Ortholog
    KLRC4, killer cell lectin like receptor C4
  • Synonyms
    NKG2-F, NKG2F
  • Links
    NCBI Gene ID: 8302
    neXtProt AC: NX_O43908
    UniProt: O43908

  • Chr Location
    12p13.2; chr12:10407384-10409757 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030167 Ensembl Gene Model | MGI Sequence Detail 12959 C57BL/6J ±  kb
    transcript ENSMUST00000032270 Ensembl | MGI Sequence Detail 1984 Not Applicable  
    polypeptide ENSMUSP00000032270 Ensembl | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • PDB
      8UMO
    • InterPro Domains
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
      IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
      IPR050919 NKG2/CD94 Natural Killer Receptors
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:51043 Vance RE, et al., Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J Exp Med. 1998 Nov 16;188(10):1841-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory