Agpat3 MGI Mouse Gene Detail - MGI:1336186 - 1-acylglycerol-3-phosphate O-acyltransferase 3

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Agpat3 Gene Detail

Symbol

Agpat3
Name

1-acylglycerol-3-phosphate O-acyltransferase 3
Synonyms

D10Jhu12e, LPAAT3

Feature Type

protein coding gene
IDs

MGI:1336186
NCBI Gene: 28169
Alliance

gene page
Transcription Start Sites

13 TSS
Candidate for QTL

3 QTL

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Sequence Map

Chr10:78105012-78188323 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

5 experiments

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SNPs within 2kb

1820 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1336186	protein coding gene	Chr10:78105008-78188335 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017420	protein coding gene	Chr10:78709109-78792298 (-)
A/J	MGP_AJ_G0017398	protein coding gene	Chr10:75970797-76055296 (-)
AKR/J	MGP_AKRJ_G0017361	protein coding gene	Chr10:78006765-78091435 (-)
BALB/cJ	MGP_BALBcJ_G0017360	protein coding gene	Chr10:76137040-76220629 (-)
C3H/HeJ	MGP_C3HHeJ_G0017183	protein coding gene	Chr10:78110514-78202761 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017816	protein coding gene	Chr10:81486355-81573258 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015507	protein coding gene	Chr10:72307393-72393649 (-)
CAST/EiJ	MGP_CASTEiJ_G0016753	protein coding gene	Chr10:78413191-78502317 (-)
CBA/J	MGP_CBAJ_G0017155	protein coding gene	Chr10:84592157-84680520 (-)
DBA/2J	MGP_DBA2J_G0017263	protein coding gene	Chr10:75212422-75296928 (-)
FVB/NJ	MGP_FVBNJ_G0017255	protein coding gene	Chr10:74389931-74474865 (-)
LP/J	MGP_LPJ_G0017334	protein coding gene	Chr10:79148005-79236107 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017282	protein coding gene	Chr10:86574658-86662327 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017858	protein coding gene	Chr10:78048486-78134853 (-)
PWK/PhJ	MGP_PWKPhJ_G0016535	protein coding gene	Chr10:75091611-75177012 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016320	protein coding gene	Chr10:77266349-77350136 (-)
WSB/EiJ	MGP_WSBEiJ_G0016813	protein coding gene	Chr10:78040027-78128444 (-)

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Human Ortholog

AGPAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGPAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3
Synonyms

1-AGPAT 3, LPAAT3, LPAAT-GAMMA1, LPLAT3
Links

HGNC:326

NCBI Gene ID: 56894

neXtProt AC: NX_Q9NRZ7

UniProt: Q9NRZ7
Chr Location

21q22.3; chr21:43865223-43987592 (+) GRCh38

MGI Vertebrate Homology

Agpat3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGPAT3
Gene Tree

Agpat3

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References

2 with disease annotations

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Phenotype Summary

25 phenotypes from 1 allele in 3 genetic backgrounds
46 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

9
Targeted

6
Genomic Mutations

4 involving Agpat3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, teratozoospermia.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

908
Tissues

165
cDNA Data

11
Literature Summary

9

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGPAT3

Xenbase agpat3

ZFIN agpat3

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All Sequences

117
RefSeq

32
UniProt

7
CCDS

CCDS23963.1

Ensembl

ENSMUSG00000001211 (Evidence)
NCBI Gene

28169

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000001211	Ensembl Gene Model \| MGI Sequence Detail	83312	C57BL/6J	± kb
	transcript	ENSMUST00000166360	Ensembl \| MGI Sequence Detail	3439	Not Applicable
	polypeptide	ENSMUSP00000132954	Ensembl \| MGI Sequence Detail	376	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003836 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

(term hierarchy)
EC

2.3.1.51
InterPro Domains

IPR032098 Acyltransferase, C-terminal domain

IPR002123 Phospholipid/glycerol acyltransferase
GlyGen

Q9D517 1 site, 1 O-linked glycan (1 site)

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All nucleic 28

Genomic 8

cDNA 14

Primer pair 4

Other 2

Microarray probesets 8

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MGI:2143803, MGI:2143842

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Summaries

All 89

Developmental Gene Expression 9

Diseases 2

Gene Ontology 5

Phenotypes 46
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Agpat3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98299	Chr10:78189471-78189479 (-)	-1,152 bp
Tssr98298	Chr10:78188303-78188349 (-)	-3 bp
Tssr98297	Chr10:78188157-78188293 (-)	98 bp
Tssr98296	Chr10:78188123-78188151 (-)	186 bp
Tssr98295	Chr10:78187931-78187948 (-)	383 bp
Tssr98294	Chr10:78187911-78187929 (-)	403 bp
Tssr98293	Chr10:78187898-78187901 (-)	423 bp
Tssr98292	Chr10:78187545-78187556 (-)	772 bp
Tssr98291	Chr10:78187524-78187542 (-)	790 bp
Tssr98290	Chr10:78156538-78156541 (-)	31,783 bp
Tssr98289	Chr10:78147849-78147864 (-)	40,466 bp
Tssr98288	Chr10:78147818-78147839 (-)	40,494 bp
Tssr98273	Chr10:78118956-78118973 (-)	69,358 bp

Agpat3 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bgeq8	Chr10, 66.75 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Igfbp3q2	Chr10, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Insq9	Chr10, 39.72 cM	Chr10:82490938-82491121	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.

*cM position of peak correlated region/marker

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