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Tsix Gene Detail
Summary
  • Symbol
    Tsix
  • Name
    X (inactive)-specific transcript, opposite strand
Location &
Maps
more
  • Sequence Map
    ChrX:102475123-102528563 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 46.13 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    998 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336196
 antisense lncRNA gene ChrX:102475123-102528563 (+)
129S1/SvImJ MGP_129S1SvImJ_G0004743
 antisense lncRNA gene ChrX:100075527-100130888 (+)
A/J MGP_AJ_G0004721
 antisense lncRNA gene ChrX:100013228-100064718 (+)
AKR/J MGP_AKRJ_G0004704
 antisense lncRNA gene ChrX:103024648-103085294 (+)
BALB/cJ MGP_BALBcJ_G0004705
 antisense lncRNA gene ChrX:98810779-98862687 (+)
C3H/HeJ MGP_C3HHeJ_G0004653
 antisense lncRNA gene ChrX:100538684-100593905 (+)
C57BL/6NJ MGP_C57BL6NJ_G0004855
 antisense lncRNA gene ChrX:103043968-103096471 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0004291
 antisense lncRNA gene ChrX:97655913-97706496 (+)
CAST/EiJ MGP_CASTEiJ_G0004610
 antisense lncRNA gene ChrX:84813518-84869396 (+)
CBA/J MGP_CBAJ_G0004647
 antisense lncRNA gene ChrX:106221991-106282286 (+)
DBA/2J MGP_DBA2J_G0004663
 antisense lncRNA gene ChrX:99256544-99309840 (+)
FVB/NJ MGP_FVBNJ_G0004681
 antisense lncRNA gene ChrX:98559438-98613886 (+)
LP/J MGP_LPJ_G0004744
 antisense lncRNA gene ChrX:101092321-101150826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0004667
 antisense lncRNA gene ChrX:110879655-110937532 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0004855
 antisense lncRNA gene ChrX:99763347-99819939 (+)
PWK/PhJ MGP_PWKPhJ_G0004561
 antisense lncRNA gene ChrX:82393056-82447144 (+)
SPRET/EiJ MGP_SPRETEiJ_G0004495
 antisense lncRNA gene ChrX:85511144-85569717 (+)
WSB/EiJ MGP_WSBEiJ_G0004653
 antisense lncRNA gene ChrX:98488121-98543615 (+)



Homology
more
  • Human Ortholog
    TSIX, TSIX transcript, XIST antisense RNA
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSIX, TSIX transcript, XIST antisense RNA
  • Synonyms
    LINC00013, NCRNA00013, XIST-AS, XISTAS, XIST-AS1
  • Links
    NCBI Gene ID: 9383

  • Chr Location
    Xq13.2; chrX:73792205-73829231 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Maternal transmission of a null allele in this imprinted gene prevents Xist accumulation disrupting X-inactivation and causing early embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    18
  • cDNA Data
    3
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      26
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22097 NCBI Gene Model | MGI Sequence Detail 53441 C57BL/6J ±  kb
    transcript NR_002844 RefSeq | MGI Sequence Detail 4306 ZRU/MplStud  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 4
      Primer pair 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 13
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:10451 Fingeroth JD, Comparative structure and evolution of murine CR2. The homolog of the human C3d/EBV receptor (CD21). J Immunol. 1990 May 1;144(9):3458-67
    • Latest
      J:324716 Samanta MK, et al., Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nat Commun. 2022 May 11;13(1):2602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory