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Lancl1 Gene Detail
Summary
  • Symbol
    Lancl1
  • Name
    LanC (bacterial lantibiotic synthetase component C)-like 1
  • Synonyms
    Gpr69a, LanC-like protein 1, p40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336997
    NCBI Gene: 14768
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:67039676-67078031 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.75 cM, cytoband C2-C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    595 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336997
 protein coding gene Chr1:67039676-67078049 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016118
 protein coding gene Chr1:67261198-67307765 (-)
A/J MGP_AJ_G0016101
 protein coding gene Chr1:64882001-64929880 (-)
AKR/J MGP_AKRJ_G0016058
 protein coding gene Chr1:66740034-66778297 (-)
BALB/cJ MGP_BALBcJ_G0016056
 protein coding gene Chr1:64966727-65006005 (-)
C3H/HeJ MGP_C3HHeJ_G0015887
 protein coding gene Chr1:66987958-67026791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016509
 protein coding gene Chr1:69865627-69907844 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014230
 protein coding gene Chr1:60820834-60861060 (-)
CAST/EiJ MGP_CASTEiJ_G0015471
 protein coding gene Chr1:66255990-66297577 (-)
CBA/J MGP_CBAJ_G0015860
 protein coding gene Chr1:72130144-72180620 (-)
DBA/2J MGP_DBA2J_G0015961
 protein coding gene Chr1:64278111-64318259 (-)
FVB/NJ MGP_FVBNJ_G0015964
 protein coding gene Chr1:63531155-63571391 (-)
LP/J MGP_LPJ_G0016033
 protein coding gene Chr1:68222228-68268455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015984
 protein coding gene Chr1:75096497-75136068 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016556
 protein coding gene Chr1:66699524-66741336 (-)
PWK/PhJ MGP_PWKPhJ_G0015258
 protein coding gene Chr1:63682769-63721793 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015037
 protein coding gene Chr1:66165305-66205378 (-)
WSB/EiJ MGP_WSBEiJ_G0015533
 protein coding gene Chr1:66424055-66468107 (-)



Homology
more
  • Human Ortholog
    LANCL1, LanC like glutathione S-transferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LANCL1, LanC like glutathione S-transferase 1
  • Synonyms
    GPR69A, p40
  • Links
    NCBI Gene ID: 10314
    neXtProt AC: NX_O43813
    UniProt: O43813

  • Chr Location
    2q34; chr2:210427131-210477652 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit postnatal neurodegeneration with increased oxidative stress and mitochondrial impairment, and reduced male fertility associated with testicular atrophy, asthenospermia, oligospermia, increased male germ cell apoptosis, and spermatozoal oxidative damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    102
  • cDNA Data
    23
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026000 Ensembl Gene Model | MGI Sequence Detail 38356 C57BL/6J ±  kb
    transcript ENSMUST00000027149 Ensembl | MGI Sequence Detail 4270 Not Applicable  
    polypeptide ENSMUSP00000027149 Ensembl | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 23
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138565
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory