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Ier5 Gene Detail
Summary
  • Symbol
    Ier5
  • Name
    immediate early response 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337072
    NCBI Gene: 15939
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:154972113-154975382 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 66.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337072
 protein coding gene Chr1:154972107-154975382 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016609
 protein coding gene Chr1:159996888-160000163 (-)
A/J MGP_AJ_G0016590
 protein coding gene Chr1:153576816-153580091 (-)
AKR/J MGP_AKRJ_G0016556
 protein coding gene Chr1:158298426-158301701 (-)
BALB/cJ MGP_BALBcJ_G0016551
 protein coding gene Chr1:154088790-154092065 (-)
C3H/HeJ MGP_C3HHeJ_G0016375
 protein coding gene Chr1:158426246-158429521 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017012
 protein coding gene Chr1:165512540-165515815 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014721
 protein coding gene Chr1:145801327-145804634 (-)
CAST/EiJ MGP_CASTEiJ_G0015955
 protein coding gene Chr1:157936272-157939545 (-)
CBA/J MGP_CBAJ_G0016350
 protein coding gene Chr1:171353808-171357083 (-)
DBA/2J MGP_DBA2J_G0016456
 protein coding gene Chr1:152554047-152557320 (-)
FVB/NJ MGP_FVBNJ_G0016454
 protein coding gene Chr1:151022670-151025945 (-)
LP/J MGP_LPJ_G0016527
 protein coding gene Chr1:161147036-161150315 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016479
 protein coding gene Chr1:178934671-178937946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017048
 protein coding gene Chr1:158103955-158107230 (-)
PWK/PhJ MGP_PWKPhJ_G0015741
 protein coding gene Chr1:151620285-151623560 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015528
 protein coding gene Chr1:156846668-156849947 (-)
WSB/EiJ MGP_WSBEiJ_G0016017
 protein coding gene Chr1:158167647-158170923 (-)



Homology
more
  • Human Ortholog
    IER5, immediate early response 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IER5, immediate early response 5
  • Synonyms
    SBBI48
  • Links
    NCBI Gene ID: 51278
    neXtProt AC: NX_Q5VY09
    UniProt: Q5VY09

  • Chr Location
    1q25.3; chr1:181088700-181092900 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Genomic Mutations
    2 involving Ier5
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    12 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    38
  • cDNA Data
    144
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15939 NCBI Gene Model | MGI Sequence Detail 3270 C57BL/6J ±  kb
transcript NM_010500 RefSeq | MGI Sequence Detail 3272 ZRU/MplStud  
polypeptide O89113 UniProt | EBI | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 147
    Genomic 2
    cDNA 144
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:53195 Williams M, et al., Ier5, a novel member of the slow-kinetics immediate-early genes. Genomics. 1999 Feb 1;55(3):327-34
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory