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Serf1 Gene Detail
Summary
  • Symbol
    Serf1
  • Name
    small EDRK-rich factor 1
  • Synonyms
    4F5, m4F5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337114
    NCBI Gene: 20365
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100244563-100250741 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.98 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337114
 protein coding gene Chr13:100244520-100251079 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020880
 protein coding gene Chr13:101940643-101952625 (+)
A/J MGP_AJ_G0020834
 protein coding gene Chr13:98017513-98030023 (+)
AKR/J MGP_AKRJ_G0020808
 protein coding gene Chr13:101012455-101018949 (+)
BALB/cJ MGP_BALBcJ_G0020832
 protein coding gene Chr13:98724619-98731425 (+)
C3H/HeJ MGP_C3HHeJ_G0020623
 protein coding gene Chr13:100731897-100739232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021266
 protein coding gene Chr13:104970598-104976933 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018835
 protein coding gene Chr13:93730970-93737782 (+)
CAST/EiJ MGP_CASTEiJ_G0020141
 protein coding gene Chr13:100175596-100184556 (+)
CBA/J MGP_CBAJ_G0020583
 protein coding gene Chr13:109143218-109149521 (+)
DBA/2J MGP_DBA2J_G0020708
 protein coding gene Chr13:97780269-97786639 (+)
FVB/NJ MGP_FVBNJ_G0020689
 protein coding gene Chr13:96525619-96532071 (+)
LP/J MGP_LPJ_G0020783
 protein coding gene Chr13:102023132-102029497 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020717
 protein coding gene Chr13:109391234-109397727 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021307
 protein coding gene Chr13:100471637-100485096 (+)
PWK/PhJ MGP_PWKPhJ_G0019894
 protein coding gene Chr13:96611972-96618527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019717
 protein coding gene Chr13:96751690-96762612 (+)
WSB/EiJ MGP_WSBEiJ_G0020199
 protein coding gene Chr13:100896698-100903571 (+)



Homology
more
  • Human Ortholog
    SERF1A, small EDRK-rich factor 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERF1A, small EDRK-rich factor 1A
  • Synonyms
    4F5, FAM2A, H4F5, SERF1, SMAM1
  • Links
    NCBI Gene ID: 8293
    neXtProt AC: NX_O75920
    UniProt: O75920

  • Chr Location
    5q13.2
  • Human Ortholog
    SERF1B, small EDRK-rich factor 1B
  • Synonyms
    FAM2B, h4F5, H4F5C
  • Links
    NCBI Gene ID: 728492
    neXtProt AC: NX_O75920
    UniProt: O75920

  • Chr Location
    5q13.2; chr5:70025251-70043113 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    28
  • cDNA Data
    78
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20365 NCBI Gene Model | MGI Sequence Detail 6179 C57BL/6J ±  kb
    transcript NM_011353 RefSeq | MGI Sequence Detail 553 ZRU/MplStud  
    polypeptide O88892 UniProt | EBI | MGI Sequence Detail 62 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      Genomic 15
      cDNA 79
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1313296
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:49474 Kim PS, et al., A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9909-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory