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Rev3l Gene Detail
Summary
  • Symbol
    Rev3l
  • Name
    REV3 like, DNA directed polymerase zeta catalytic subunit
  • Synonyms
    Rev, Sez4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337131
    NCBI Gene: 19714
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:39608114-39751207 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 21.04 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2861 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337131
 protein coding gene Chr10:39607557-39751207 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017153
 protein coding gene Chr10:38255434-38401069 (+)
A/J MGP_AJ_G0017130
 protein coding gene Chr10:37233266-37373085 (+)
AKR/J MGP_AKRJ_G0017090
 protein coding gene Chr10:37751359-37893735 (+)
BALB/cJ MGP_BALBcJ_G0017093
 protein coding gene Chr10:37277245-37439980 (+)
C3H/HeJ MGP_C3HHeJ_G0016913
 protein coding gene Chr10:38078471-38221603 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017551
 protein coding gene Chr10:39424620-39579179 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015248
 protein coding gene Chr10:35216981-35366345 (+)
CAST/EiJ MGP_CASTEiJ_G0016492
 protein coding gene Chr10:38238556-38391366 (+)
CBA/J MGP_CBAJ_G0016887
 protein coding gene Chr10:41251091-41402299 (+)
DBA/2J MGP_DBA2J_G0016992
 protein coding gene Chr10:36753742-36898022 (+)
FVB/NJ MGP_FVBNJ_G0016987
 protein coding gene Chr10:36258459-36399532 (+)
LP/J MGP_LPJ_G0017069
 protein coding gene Chr10:38227194-38374280 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017017
 protein coding gene Chr10:42090955-42255812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017588
 protein coding gene Chr10:37740237-37885153 (+)
PWK/PhJ MGP_PWKPhJ_G0016273
 protein coding gene Chr10:36598112-36739541 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016057
 protein coding gene Chr10:37538402-37682915 (+)
WSB/EiJ MGP_WSBEiJ_G0016555
 protein coding gene Chr10:38016922-38164019 (+)



Homology
more
  • Human Ortholog
    REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit
  • Synonyms
    POLZ, REV3
  • Links
    NCBI Gene ID: 5980
    neXtProt AC: NX_O60673
    UniProt: O60673

  • Chr Location
    6q21; chr6:111299028-111483715 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 10 alleles in 7 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit complete embryonic lethality and abnormal embryonic tissue morphology with widespread degeneration and cell death. Mice carrying the amino acid substitution of phenylalanine for leucine at position 2610 display alterations in somatic hypermutation frequency and specificity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    160
  • cDNA Data
    117
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019841 Ensembl Gene Model | MGI Sequence Detail 143094 C57BL/6J ±  kb
    transcript ENSMUST00000019986 Ensembl | MGI Sequence Detail 10713 Not Applicable  
    polypeptide ENSMUSP00000019986 Ensembl | MGI Sequence Detail 3122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013900 DNA polymerase zeta catalytic subunit
      (term hierarchy)
    • PDB
      4FJO
    • EC
      2.7.7.7
    • InterPro Domains
      IPR025687 C4-type zinc-finger of DNA polymerase delta
      IPR006172 DNA-directed DNA polymerase, family B
      IPR017964 DNA-directed DNA polymerase, family B, conserved site
      IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
      IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
      IPR042087 DNA polymerase family B, thumb domain
      IPR023211 DNA polymerase, palm domain superfamily
      IPR030559 DNA polymerase zeta catalytic subunit
      IPR043502 DNA/RNA polymerase superfamily
      IPR032757 Domain of unknown function DUF4683
      IPR042794 Neurite extension and migration factor
      IPR012337 Ribonuclease H-like superfamily
      IPR036397 Ribonuclease H superfamily
    Molecular
    Reagents
    less
    • All nucleic 119
      Genomic 1
      cDNA 117
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39490, MGI:109491
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory