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Gdap1 Gene Detail
Summary
  • Symbol
    Gdap1
  • Name
    ganglioside-induced differentiation-associated-protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338002
    NCBI Gene: 14545
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:17215586-17234495 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 5.21 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    604 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338002
 protein coding gene Chr1:17202028-17234513 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015861
 protein coding gene Chr1:14675961-14696130 (+)
A/J MGP_AJ_G0015842
 protein coding gene Chr1:14483200-14502634 (+)
AKR/J MGP_AKRJ_G0015801
 protein coding gene Chr1:14503738-14522211 (+)
BALB/cJ MGP_BALBcJ_G0015798
 protein coding gene Chr1:14195031-14215085 (+)
C3H/HeJ MGP_C3HHeJ_G0015632
 protein coding gene Chr1:14549138-14570121 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016252
 protein coding gene Chr1:15338897-15359833 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013973
 protein coding gene Chr1:13042097-13060814 (+)
CAST/EiJ MGP_CASTEiJ_G0015213
 protein coding gene Chr1:14587651-14612541 (+)
CBA/J MGP_CBAJ_G0015605
 protein coding gene Chr1:15657603-15682619 (+)
DBA/2J MGP_DBA2J_G0015704
 protein coding gene Chr1:14098054-14117432 (+)
FVB/NJ MGP_FVBNJ_G0015709
 protein coding gene Chr1:13857569-13876006 (+)
LP/J MGP_LPJ_G0015776
 protein coding gene Chr1:14864809-14885741 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015728
 protein coding gene Chr1:16312955-16332846 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016299
 protein coding gene Chr1:14472602-14491746 (+)
PWK/PhJ MGP_PWKPhJ_G0014997
 protein coding gene Chr1:13831262-13852441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014778
 protein coding gene Chr1:14624185-14642526 (+)
WSB/EiJ MGP_WSBEiJ_G0015276
 protein coding gene Chr1:14419566-14440929 (+)



Homology
more
  • Human Ortholog
    GDAP1, ganglioside induced differentiation associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDAP1, ganglioside induced differentiation associated protein 1
  • Synonyms
    CMT4, CMT4A, CMTRIA
  • Links
    NCBI Gene ID: 54332
    neXtProt AC: NX_Q8TB36
    UniProt: Q8TB36

  • Chr Location
    8q21.11; chr8:74320613-74518007 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gdap1 mouse models; 5 with human GDAP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop motor deficits and a peripheral neuropathy with loss of motor neurons and abnormal neuromuscular junctions. Cultured motor neurons show large and abnormal mitochondria, reduced axon length, changes in the ER cisternae, and altered calcium ion homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    40
  • cDNA Data
    42
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025777 Ensembl Gene Model | MGI Sequence Detail 18910 C57BL/6J ±  kb
    transcript ENSMUST00000026879 Ensembl | MGI Sequence Detail 3949 Not Applicable  
    polypeptide ENSMUSP00000026879 Ensembl | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007912 ganglioside-induced differentiation-associated protein 1
      (term hierarchy)
    • PDB
      8EXZ
    • InterPro Domains
      IPR034336 Ganglioside-induced differentiation-associated protein 1, C-terminal domain
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR010987 Glutathione S-transferase, C-terminal-like
      IPR004045 Glutathione S-transferase, N-terminal
      IPR040079 Glutathione transferase family
      IPR036249 Thioredoxin-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 45
      Primer pair 1
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:54635 Liu H, et al., Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. J Neurochem. 1999 May;72(5):1781-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory