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Rnd2 Gene Detail
Summary
  • Symbol
    Rnd2
  • Name
    Rho family GTPase 2
  • Synonyms
    Arhn, Rohn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338755
    NCBI Gene: 11858
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101359001-101362679 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.12 cM, cytoband C-D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338755
 protein coding gene Chr11:101355825-101362679 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019205
 protein coding gene Chr11:104333006-104339637 (+)
A/J MGP_AJ_G0019173
 protein coding gene Chr11:99946759-99953390 (+)
AKR/J MGP_AKRJ_G0019142
 protein coding gene Chr11:103053330-103060162 (+)
BALB/cJ MGP_BALBcJ_G0019147
 protein coding gene Chr11:100439287-100446119 (+)
C3H/HeJ MGP_C3HHeJ_G0018956
 protein coding gene Chr11:103229884-103236515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019596
 protein coding gene Chr11:107607680-107614464 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017222
 protein coding gene Chr11:97344776-97351427 (+)
CAST/EiJ MGP_CASTEiJ_G0018510
 protein coding gene Chr11:104208715-104215310 (+)
CBA/J MGP_CBAJ_G0018925
 protein coding gene Chr11:112036234-112043023 (+)
DBA/2J MGP_DBA2J_G0019037
 protein coding gene Chr11:99468845-99475508 (+)
FVB/NJ MGP_FVBNJ_G0019027
 protein coding gene Chr11:99011124-99017948 (+)
LP/J MGP_LPJ_G0019106
 protein coding gene Chr11:104872581-104879068 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019058
 protein coding gene Chr11:111592164-111598786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019634
 protein coding gene Chr11:103382982-103389583 (+)
PWK/PhJ MGP_PWKPhJ_G0018273
 protein coding gene Chr11:100530947-100537960 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018065
 protein coding gene Chr11:103109621-103116246 (+)
WSB/EiJ MGP_WSBEiJ_G0018559
 protein coding gene Chr11:103379437-103386061 (+)



Homology
more
  • Human Ortholog
    RND2, Rho family GTPase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RND2, Rho family GTPase 2
  • Synonyms
    ARHN, RHO7, RhoN
  • Links
    NCBI Gene ID: 8153
    neXtProt AC: NX_P52198
    UniProt: P52198

  • Chr Location
    17q21.31; chr17:43025231-43032041 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Oligodenddrocyte-specific knock-out mice exhibit decreased myelin thickness at the onset of myelination but increased myelin thickness in the later period.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    18
  • cDNA Data
    32
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11858 NCBI Gene Model | MGI Sequence Detail 3679 C57BL/6J ±  kb
    transcript NM_009708 RefSeq | MGI Sequence Detail 1406 C57BL/6  
    polypeptide Q9QYM5 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 34
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 21
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:54016 Nishi M, et al., RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells. Brain Res Mol Brain Res. 1999 Apr 6;67(1):74-81
    • Latest
      J:352990 Yang J, et al., Spatial transcriptome reveals the region-specific genes and pathways regulated by Satb2 in neocortical development. BMC Genomics. 2024 Aug 2;25(1):757
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory