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Il18rap Gene Detail
Summary
  • Symbol
    Il18rap
  • Name
    interleukin 18 receptor accessory protein
  • Synonyms
    AcPL accessory protein-like)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338888
    NCBI Gene: 16174
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:40554548-40590867 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 19.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1202 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338888
 protein coding gene Chr1:40554522-40590867 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015969
 protein coding gene Chr1:39313874-39352831 (+)
A/J MGP_AJ_G0015953
 protein coding gene Chr1:38202158-38238842 (+)
AKR/J MGP_AKRJ_G0015908
 protein coding gene Chr1:38678088-38711965 (+)
BALB/cJ MGP_BALBcJ_G0015907
 protein coding gene Chr1:37863404-37900017 (+)
C3H/HeJ MGP_C3HHeJ_G0015740
 protein coding gene Chr1:38984419-39019544 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016360
 protein coding gene Chr1:40926776-40964159 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014082
 protein coding gene Chr1:35127870-35159264 (+)
CAST/EiJ MGP_CASTEiJ_G0015321
 protein coding gene Chr1:38877004-38911438 (+)
CBA/J MGP_CBAJ_G0015712
 protein coding gene Chr1:42130199-42176404 (+)
DBA/2J MGP_DBA2J_G0015813
 protein coding gene Chr1:37478174-37515280 (+)
FVB/NJ MGP_FVBNJ_G0015815
 protein coding gene Chr1:37023243-37058534 (+)
LP/J MGP_LPJ_G0015883
 protein coding gene Chr1:39648338-39685240 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015835
 protein coding gene Chr1:44140762-44180439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016407
 protein coding gene Chr1:38837277-38872686 (+)
PWK/PhJ MGP_PWKPhJ_G0015104
 protein coding gene Chr1:37291270-37327021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014886
 protein coding gene Chr1:38812615-38845271 (+)
WSB/EiJ MGP_WSBEiJ_G0015383
 protein coding gene Chr1:38805944-38841114 (+)



Homology
more
  • Human Ortholog
    IL18RAP, interleukin 18 receptor accessory protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL18RAP, interleukin 18 receptor accessory protein
  • Synonyms
    ACPL, CD218b, CDw218b, IL-18RAcP, IL18RB, IL-18R-beta, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL
  • Links
    NCBI Gene ID: 8807
    neXtProt AC: NX_O95256
    UniProt: O95256

  • Chr Location
    2q12.1; chr2:102418621-102452565 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    1
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16174 NCBI Gene Model | MGI Sequence Detail 36320 C57BL/6J ±  kb
    transcript NM_010553 RefSeq | MGI Sequence Detail 4856 C57BL/6  
    polypeptide Q9Z2B1 UniProt | EBI | MGI Sequence Detail 614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 1
      cDNA 4
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:50863 Born TL, et al., Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem. 1998 Nov 6;273(45):29445-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory