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Muc2 Gene Detail
Summary
  • Symbol
    Muc2
  • Name
    mucin 2
  • Synonyms
    2010015E03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339364
    NCBI Gene: 17831
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141276583-141308428 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.10 cM, cytoband F5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    631 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339364
 protein coding gene Chr7:141276583-141308430 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033240
 protein coding gene Chr7:146900982-146935561 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033734
 protein coding gene Chr7:152261356-152297828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030707
 protein coding gene Chr7:143896091-143925064 (+)
CAST/EiJ MGP_CASTEiJ_G0032267
 protein coding gene Chr7:138720754-138754778 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0033156
 protein coding gene Chr7:148390207-148421820 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0033753
 protein coding gene Chr7:145616050-145648240 (+)
PWK/PhJ MGP_PWKPhJ_G0031971
 protein coding gene Chr7:133930187-133961216 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032377
 protein coding gene Chr7:146575415-146608092 (+)



Homology
more
  • Human Ortholog
    MUC2, mucin 2, oligomeric mucus/gel-forming
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MUC2, mucin 2, oligomeric mucus/gel-forming
  • Synonyms
    MLP, MUC-2, SMUC
  • Links
    NCBI Gene ID: 4583
    UniProt: Q02817

  • Chr Location
    11p15.5; chr11:1074874-1110511 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Muc2 mouse models; 1 with human MUC2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 7 alleles in 8 genetic backgrounds
    8 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a point mutation have soft feces at weaning and develop diarrhea associated with malapsorption syndrome. Homozygous null mutants pass blood in their feces at 6 months, and 65% of null mutants have intestinal tumors at 1 year.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    17
  • cDNA Data
    3
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      38
    • RefSeq
      2
    • UniProt
      7
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17831 NCBI Gene Model | MGI Sequence Detail 31846 C57BL/6J ±  kb
    transcript NM_023566 RefSeq | MGI Sequence Detail 13914 ZRU/MplStud  
    polypeptide Q80Z19 UniProt | EBI | MGI Sequence Detail 4576 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR006207 Cystine knot, C-terminal
      IPR006208 Glycoprotein hormone subunit beta
      IPR050780 Mucin/von Willebrand/Thrombospondin superfamily
      IPR036084 Serine protease inhibitor-like superfamily
      IPR002919 Trypsin Inhibitor-like, cysteine rich domain
      IPR001846 von Willebrand factor, type D domain
      IPR001007 VWFC domain
      IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain
      IPR025155 WxxW domain
    • GlyGen
      Q80Z19 40 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 3
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917597, MGI:3584408
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 35
      Diseases 2
      Gene Ontology 12
      Phenotypes 69
    • Earliest
      J:52364 van Klinken BJ, et al., Gastrointestinal expression and partial cDNA cloning of murine Muc2. Am J Physiol. 1999 Jan;276(1 Pt 1):G115-24
    • Latest
      J:357396 Devereaux J, et al., Alterations in tryptophan metabolism and de novo NAD(+) biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation. Front Med (Lausanne). 2024;11:1379335
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory